Sedaghattalab Moslem, Razazan Marzieh, Sadeghi Hossein, Doustimotlagh Amir Hossein, Toori Mehdi Akbartabar, Abbasi Larki Rozina, Azarmehr Nahid, Asfaram Arash, Panahi Kokhdan Esmaeel, Taheri Tahere, Pourshohod Aminollah
Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran.
Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
Evid Based Complement Alternat Med. 2021 Jan 8;2021:1632957. doi: 10.1155/2021/1632957. eCollection 2021.
Increased oxidative stress play an important role in the risk of cardiovascular disease, mortality, and mortality patients undergoing dialysis. (watercress) contains numerous phytochemical compounds that act as an antioxidant by preventing oxidative damage to biomolecules. Therefore, this research aimed to explore the effect of the ethanolic extract of (EENO) on antioxidant and biochemical markers of hemodialysis patients.
In this double-blind, placebo-controlled trial, 46 hemodialysis patients were randomly recruited to consume either 500 mg/day EENO ( = 23) or placebo capsule ( = 23) for 4 weeks, at Shahid Beheshti Hospital, Yasuj, Iran, in 2019. Biomarkers of oxidative stress including glutathione peroxidase (GPX), superoxide dismutase (SOD), malondialdehyde (MDA), total oxidant status (TOS), total antioxidant capacity (TAC), and total sulfhydryl protein (T-SH) and biochemical parameters such as BUN, Hb, WBC, PLT, Ca, Ph, K, ALB, TChol, TG, LDL, and HDL were evaluated on days 0 and 28.
The serum levels of MDA and BUN significantly decreased after taking EENO supplementation ( < 0.001); however, SOD activity increased during the same period ( < 0.001). The serum levels of TAC remained constant in the intervention group, while it significantly declined in the placebo group ( < 0.09). The extract also prevented elevation in the serum levels of LDL and TG compared to the placebo group, although it was not statistically significant.
The data indicated that the consumption of EENO improved some of the antioxidant parameters and minimizes the change in TG and LDL in hemodialysis patients. Therefore, due to the role of these factors in mortality and morbidity of dialysis patients, EENO can improve the condition of dialysis patients. However, more studies with longer intervention times and different doses of EENO are recommended.
氧化应激增加在心血管疾病风险、死亡率以及透析患者死亡率中起重要作用。豆瓣菜含有多种植物化学化合物，通过防止生物分子的氧化损伤发挥抗氧化作用。因此，本研究旨在探讨豆瓣菜乙醇提取物（EENO）对血液透析患者抗氧化和生化指标的影响。
在这项双盲、安慰剂对照试验中，2019年于伊朗亚苏杰的沙希德·贝赫什提医院，随机招募了46名血液透析患者，让他们连续4周每天服用500毫克EENO（n = 23）或安慰剂胶囊（n = 23）。在第0天和第28天评估氧化应激生物标志物，包括谷胱甘肽过氧化物酶（GPX）、超氧化物歧化酶（SOD）、丙二醛（MDA）、总氧化剂状态（TOS）、总抗氧化能力（TAC）和总巯基蛋白（T-SH），以及生化参数，如血尿素氮（BUN）、血红蛋白（Hb）、白细胞（WBC）、血小板（PLT）、钙（Ca）、磷（Ph）、钾（K）、白蛋白（ALB）、总胆固醇（TChol）、甘油三酯（TG）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）。
服用EENO补充剂后，MDA和BUN的血清水平显著降低（P < 0.001）；然而，同期SOD活性增加（P < 0.001）。干预组TAC的血清水平保持不变，而安慰剂组则显著下降（P < 0.09）。与安慰剂组相比，该提取物还可防止LDL和TG的血清水平升高，尽管差异无统计学意义。
数据表明，服用EENO可改善血液透析患者的一些抗氧化参数，并使TG和LDL的变化最小化。因此，鉴于这些因素在透析患者死亡率和发病率中的作用，EENO可改善透析患者的状况。然而，建议进行更多干预时间更长、EENO剂量不同的研究。
