Zandi Milad, Hosseini Parastoo, Soltani Saber, Rasooli Azadeh, Moghadami Mona, Nasimzadeh Sepideh, Behnezhad Farzane
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran.
Osong Public Health Res Perspect. 2021 Oct;12(5):278-285. doi: 10.24171/j.phrp.2021.0153. Epub 2021 Oct 15.
Coronaviruses, which have been known to cause diseases in animals since the 1930s, utilize cellular components during their replication cycle. Lipids play important roles in viral infection, as coronaviruses target cellular lipids and lipid metabolism to modify their host cells to become an optimal environment for viral replication. Therefore, lipids can be considered as potential targets for the development of antiviral agents. This review provides an overview of the roles of cellular lipids in different stages of the life cycle of coronaviruses.
自20世纪30年代以来，冠状病毒就已知会在动物中引发疾病，它们在复制周期中利用细胞成分。脂质在病毒感染中发挥着重要作用，因为冠状病毒靶向细胞脂质和脂质代谢，以改变其宿主细胞，使其成为病毒复制的最佳环境。因此，脂质可被视为抗病毒药物开发的潜在靶点。本文综述了细胞脂质在冠状病毒生命周期不同阶段中的作用。
