Teng C M, Chen C C, Ko F N, Lee L G, Huang T F, Chen Y P, Hsu H Y
Pharmacological Institute, College of Medicine, National Taiwan University, Taipei.
Thromb Res. 1988 Jun 15;50(6):757-65. doi: 10.1016/0049-3848(88)90336-2.
Magnolol and honokiol are two position isomers isolated from the bark of Magnolia officinalis. Both inhibited the aggregation and ATP release of rabbit platelet-rich plasma induced by collagen and arachidonic acid without affecting that induced by ADP, PAF or thrombin. Aggregation of washed platelets was more markedly inhibited than that of platelet-rich plasma, while the aggregation of whole blood was least affected by both inhibitors. Thromboxane B2 formation caused by collagen, arachidonic acid or thrombin was in each case inhibited by magnolol and honokiol. The rise of intracellular calcium caused by arachidonic acid or collagen was also suppressed by both agents. Collagen-induced intracellular calcium increase in the presence of indomethacin was suppressed by magnolol. It is concluded that the antiplatelet effect of magnolol and honokiol is due to an inhibitory effect on thromboxane formation and also an inhibition of intracellular calcium mobilization.
厚朴酚与和厚朴酚是从厚朴树皮中分离得到的两种位置异构体。二者均能抑制胶原蛋白和花生四烯酸诱导的兔富血小板血浆的聚集及ATP释放，而不影响ADP、PAF或凝血酶诱导的聚集。与富血小板血浆相比，二者对洗涤血小板聚集的抑制作用更为显著，而对全血聚集的影响最小。厚朴酚与和厚朴酚均可抑制胶原蛋白、花生四烯酸或凝血酶诱导的血栓素B2的生成。二者还可抑制花生四烯酸或胶原蛋白引起的细胞内钙升高。在吲哚美辛存在的情况下，厚朴酚可抑制胶原蛋白诱导的细胞内钙增加。得出的结论是，厚朴酚与和厚朴酚的抗血小板作用是由于对血栓素生成的抑制作用以及对细胞内钙动员的抑制作用。
