尿可替宁水平与咀嚼无烟烟草者心血管自主功能测试之间的相关性：一项横断面研究。

Correlation between cotinine urinary levels & cardiovascular autonomic function tests among smokeless tobacco chewers: A cross-sectional study.

机构信息

Department of Physiology, Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India.

Department of Physiology, Krishna Institute of Medical Sciences, Deemed University, Karad, Maharashtra, India.

出版信息

Indian J Med Res. 2020 Dec;152(6):633-637. doi: 10.4103/ijmr.IJMR_1815_18.

DOI:10.4103/ijmr.IJMR_1815_18

PMID:34145103

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8224156/

Abstract

BACKGROUND & OBJECTIVES: Cardiovascular disease (CVD), the leading cause of death worldwide is responsible for over 17 million deaths globally, of which 10 per cent deaths have been expected due to consumption of tobacco. The association between CVD and chewing of tobacco is limited and remains arguable. The aim of this study was to find out the correlation between urinary cotinine level and cardiovascular autonomic function tests of tobacco chewers.

METHODS

In the present study, 600 participants, 300 smokeless tobacco chewers (STC) and 300 non-tobacco chewers (NTC), between 18 and 65 yr were selected. Various parameters such as anthropometric, systolic blood pressure (SBP), diastolic blood pressure (DBP), autonomic function tests and urinary cotinine levels were measured.

RESULTS

Significant difference (P<0.001) was noted in STC and NTC for anthropometric parameters, SBP, DBP and urinary cotinine levels. Sympathetic and parasympathetic autonomic function test showed significant difference on comparison in STC and NTC groups, except in Valsalva ratio. Correlations with urinary cotinine levels were significant for sympathetic autonomic functions, SBP fall (r=0.138, P=0.016), DBP rise (r=-0.141, P≤0.014); parasympathetic autonomic function, heart rate (HR) response to standing (r=-0.208, P≤0.003), deep breathing (r=-0.473, P≤0.001) and Valsalva ratio (r=-0.396, P≤0.0001).

INTERPRETATION & CONCLUSIONS: Correlation between urinary cotinine levels and autonomic function tests elucidates the linkage involving autonomic nervous system damage which can be considered as an important associated relationship for early diagnosis of CVD health risk factors among smokeless tobacco (ST) users.

摘要

背景与目的

心血管疾病（CVD）是全球首要死因，导致全球 1700 多万人死亡，其中 10%的死亡归因于烟草消费。心血管疾病与咀嚼烟草之间的关联有限，仍存在争议。本研究旨在探讨尿可替宁水平与咀嚼烟草者心血管自主功能测试之间的相关性。

方法

本研究纳入了 600 名参与者，包括 300 名非吸烟型烟草咀嚼者（STC）和 300 名非烟草咀嚼者（NTC），年龄在 18 至 65 岁之间。测量了各种参数，如人体测量学、收缩压（SBP）、舒张压（DBP）、自主功能测试和尿可替宁水平。

结果

STC 和 NTC 在人体测量学参数、SBP、DBP 和尿可替宁水平方面存在显著差异（P<0.001）。在 STC 和 NTC 组之间，自主神经功能测试的交感和副交感功能均存在显著差异，但瓦尔萨尔瓦比值除外。与尿可替宁水平的相关性在交感自主功能方面具有统计学意义，SBP 下降（r=0.138，P=0.016），DBP 升高（r=-0.141，P≤0.014）；副交感自主功能方面，心率对站立（r=-0.208，P≤0.003）、深呼吸（r=-0.473，P≤0.001）和瓦尔萨尔瓦比值（r=-0.396，P≤0.0001）的反应。