Geliebter A, Westreich S, Gage D
Department of Medicine, St Luke's-Roosevelt Hospital Center, New York, NY 10025.
Am J Clin Nutr. 1988 Sep;48(3):592-4. doi: 10.1093/ajcn/48.3.592.
A study was conducted to determine the effects of various levels of gastric distension on spontaneous meal intake. A balloon was inserted into the stomach of four lean and four obese subjects before consumption of a lunch meal. On different days the balloon was filled with 0, 200, 400, 600, and 800 mL water in a random sequence. As balloon volume increased, food intake decreased, with a balloon volume of greater than or equal to 400 mL significantly reducing intake (p less than 0.01). There was no significant difference between lean and obese subjects. Because gastric emptying rate was not significantly slowed by a volume of 800 mL, between emptying was probably not a factor in inducing satiety. Discomfort was probably also not a factor because it was experienced by only two lean subjects at 800 mL. Most likely gastric distension itself triggered satiety signals.
开展了一项研究以确定不同程度的胃扩张对自发进食量的影响。在四名瘦人和四名肥胖受试者食用午餐前，将一个气球插入他们的胃中。在不同的日子里，气球以随机顺序充入0、200、400、600和800毫升水。随着气球体积的增加，食物摄入量减少，当气球体积大于或等于400毫升时，摄入量显著减少（p小于0.01）。瘦人和肥胖受试者之间没有显著差异。由于800毫升的体积并未使胃排空率显著减慢，胃排空可能不是诱导饱腹感的因素。不适可能也不是一个因素，因为只有两名瘦人在800毫升时出现了不适。最有可能的是胃扩张本身触发了饱腹感信号。
