A prospective comparison of platelet collection with the CS-3000 blood cell separator using the closed system and open system kits.

Each of 30 donors had two plateletapheresis procedures on the CS-3000 Blood Cell Separator (Fenwal Laboratories, Deerfield, IL). During one procedure, platelets were collected with the Closed System Apheresis Kit for Extended Platelet Storage (Fenwal); during the other procedure the Open System Apheresis Kit (Fenwal) was used. The same operator performed the entire collection process and all laboratory studies for both procedures for each donor. There was a statistically significant lower yield with the Closed System Kit (mean: 4.51 x 10(11) platelets) than with the Open System Kit (mean: 4.76 x 10(11) platelets) (P = 0.03). There was no significant difference in lymphocyte contamination. The relatively small magnitude of the difference, however, means that product quality, longer storage time, and cost are more important considerations in selecting a kit for use.