Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
Drug Alcohol Depend. 2021 Aug 1;225:108744. doi: 10.1016/j.drugalcdep.2021.108744. Epub 2021 May 20.
Cocaine use is broadly associated with risky sexual behavior potentially through elevated sexual desire. Understanding the within-person effects of cocaine on sexual desire and risky sexual behavior and the modification of HIV infection may inform primary and secondary HIV interventions.
We conducted a mobile health (mHealth) study in a community sample of males and females with (n = 28) and without (n = 32) HIV who use illicit stimulant drugs. Participants completed ecological momentary assessments (EMAs) and daily diaries over 28 days. Mixed effects models were employed to examine the within-person association of cocaine use with sexual desire and risky sexual behavior.
Participants completed 3505 EMA responses, with 36 % involving recent cocaine use, including powder and/or crack cocaine. They completed 1427 daily diary responses, with cocaine use reported on 49 % of these days and sexual behavior on 21 % of these days. Sexual desire was highest in the first hour since cocaine use and gradually decreased with time. Sexual desire was lowest when participants had not used any cocaine in the past 6 h, and it correlated positively with the amount of use. Participants were more likely to have risky sexual behavior on days they used cocaine. These associations were similar for participants with and without HIV.
This study demonstrates the dynamic and proximal effects of cocaine use on sexual desire and risky sexual behavior. Our findings support the development of HIV prevention interventions that utilize mHealth technology to reduce sexual risk behavior among persons who use stimulant drugs.
可卡因的使用与危险的性行为广泛相关,可能是通过提高性欲。了解可卡因对性欲和危险性行为的个体内影响,以及对 HIV 感染的修饰,可以为初级和二级 HIV 干预措施提供信息。
我们在一个有(n=28)和没有(n=32)HIV 的男性和女性的社区样本中进行了一项移动健康(mHealth)研究,这些人使用非法兴奋剂药物。参与者完成了 28 天的生态瞬时评估(EMA)和每日日记。混合效应模型用于研究可卡因使用与性欲和危险性行为的个体内关联。
参与者完成了 3505 次 EMA 反应,其中 36%涉及最近的可卡因使用,包括粉末和/或可卡因。他们完成了 1427 份每日日记,其中 49%的日子报告了可卡因使用,21%的日子报告了性行为。性欲望在使用可卡因后的第一个小时最高,随着时间的推移逐渐下降。当参与者在过去 6 小时内没有使用任何可卡因时,性欲望最低,并且与使用量呈正相关。参与者在使用可卡因的日子里更有可能进行危险的性行为。这些关联在有和没有 HIV 的参与者中是相似的。
这项研究表明了可卡因使用对性欲和危险性行为的动态和直接影响。我们的发现支持开发 HIV 预防干预措施,利用 mHealth 技术减少使用兴奋剂药物的人发生性行为的风险。