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[关于新型冠状病毒肺炎疫苗诱导的血栓形成、出血和血小板减少症的指南]

[Guidelines on: COVID-19 Vaccine Induced Thrombosis, Bleeding, and Thrombocytopenia].

作者信息

Morais Sara, Cruz Eugénia

机构信息

Unidade de Trombose e Hemostase. Serviço de Hematologia Clínica. Hospital de Santo António. Centro Hospitalar Universitário do Porto. Porto; Unidade Multidisciplinar de Investigação Biomédica. Instituto de Ciências Biomédicas. Universidade do Porto. Porto. Portugal.

Unidade de Trombose e Hemostase. Serviço de Hematologia Clínica. Hospital de Santo António. Centro Hospitalar Universitário do Porto. Porto. Basic and Clinical Research on Iron Biology Group. Instituto de Investigação e Inovação em Saúde - i3S. Universidade do Porto. Porto. Portugal.

出版信息

Acta Med Port. 2021 Aug 31;34(9):625-629. doi: 10.20344/amp.16602. Epub 2021 Jun 18.

Abstract

After widespread vaccination with COVID-19 vaccines, there have been worldwide reports on thrombosis, bleeding, and thrombocytopenia. Recently, a rare syndrome with a high mortality rate consisting of an unusual combination of thrombocytopenia and thrombosis, in particular cerebral venous sinus thrombosis, which clinically resembles heparin-induced thrombocytopenia, was reported following vaccination. Different statements and recommendations were developed regarding the definition, diagnosis, and treatment of these rare complications. We present here a protocol with recommendations, based on current evidence.

摘要

在广泛接种新冠疫苗后,全球出现了关于血栓形成、出血和血小板减少的报道。最近,有报道称接种疫苗后出现了一种罕见综合征,其死亡率很高,由血小板减少和血栓形成,特别是脑静脉窦血栓形成的异常组合构成,临床上类似于肝素诱导的血小板减少症。针对这些罕见并发症的定义、诊断和治疗,出现了不同的声明和建议。我们在此根据现有证据提出一份包含建议的方案。

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