Levy Ryan M, Luketich James D, Brynien Daniel, Mpamaugo Chinenyenwa, Shende Manisha R, Gooding William E, Pennathur Arjun
Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pa.
UPMC Hillman Cancer Center Biostatistics Facility, Pittsburgh, Pa.
J Thorac Cardiovasc Surg. 2022 Jun;163(6):1965-1974.e1. doi: 10.1016/j.jtcvs.2020.12.151. Epub 2021 Mar 10.
Zenker diverticulum (ZD), a pulsion diverticulum of the esophagus, has been traditionally managed with an open surgical approach, but endoscopic transoral stapling has been reported with increasing frequency. The objective of this study was to evaluate the results of endoscopic repair of ZD by a thoracic surgery service.
We conducted a retrospective review of patients who underwent transoral stapling repair of ZD at our institution by the thoracic surgery service. We evaluated perioperative outcomes including dysphagia (1, no dysphagia to 5, unable to swallow saliva) and failure of repair requiring surgical intervention.
A total of 151 patients (median age, 78 years; 75 men, 76 women) underwent evaluation for endoscopic repair of ZD. Endoscopic stapled repair of the ZD was completed in 135. Sixteen patients underwent conversion to open repair. The perioperative mortality was 0.6% (1 patient). The median hospital stay was 2 days (range, 0-18 days). Complications occurred in 5 patients who underwent endoscopic repair. The mean preoperative dysphagia score was 2.8 and improved to 1.2 during follow-up (median, 16 months; P < .001). During further follow-up (median, 52 months), 8 patients (5.3%) had failure of the endoscopic repair requiring open surgery (n = 5) or redo transoral stapling (n = 3).
Endoscopic stapling repair of ZD can be performed safely with good results in experienced centers by thoracic surgeons with significant esophageal experience. Long-term follow-up is required to evaluate the durability of endoscopic repair of ZD.
Zenker憩室(ZD)是一种食管的牵引性憩室,传统上采用开放手术治疗,但内镜经口吻合术的报道频率日益增加。本研究的目的是评估胸外科服务部门对ZD进行内镜修复的结果。
我们对在本机构接受胸外科服务部门经口吻合修复ZD的患者进行了回顾性研究。我们评估了围手术期结果,包括吞咽困难(1级,无吞咽困难至5级,无法吞咽唾液)以及修复失败需要手术干预的情况。
共有151例患者(中位年龄78岁;男性75例,女性76例)接受了ZD内镜修复评估。135例完成了ZD的内镜吻合修复。16例患者转为开放修复。围手术期死亡率为0.6%(1例患者)。中位住院时间为2天(范围0 - 18天)。5例接受内镜修复的患者出现了并发症。术前吞咽困难平均评分为2.8分,随访期间(中位时间16个月)改善至1.2分(P < 0.001)。在进一步随访(中位时间52个月)中,8例患者(5.3%)内镜修复失败,需要进行开放手术(n = 5)或再次经口吻合(n = 3)。
在有丰富食管手术经验的胸外科医生所在的经验丰富的中心,ZD的内镜吻合修复可以安全进行且效果良好。需要长期随访以评估ZD内镜修复的持久性。