Kalofiri Paraskevi, Balias Giorgos, Tekos Fotios
Harokopio University of Athens, Greece.
Department of Biochemistry-Biotechnology, University of Thessaly, Larissa, Greece.
Toxicol Rep. 2021 Jun 3;8:1193-1199. doi: 10.1016/j.toxrep.2021.05.013. eCollection 2021.
Endocrine disruptors are compounds that alter the functioning of the endocrine system of humans and wildlife. A large number of chemicals have been identified as EDs and humans can be exposed to them through dietary and/or environmental exposure (air, water, soil). At international level, scientific discussion on the topic of EDs focuses on the issue of setting out the scientific criteria according to which the key properties of these substances that render them EDs are determined. Regulatory action in EU has been impacted by the aforementioned discussion and, in particular, Regulation 2017/2100 and Regulation 2018/605 have been issued. However, these scientific criteria do not constitute a complete framework for the detection of EDs and, therefore, their adoption does not entail a fully effective human health protection. Moreover, glyphosate-based herbicides (GBH), are the most widely used pesticides worldwide. The glyphosate controversy turned the spotlight on pesticide regulation in the EU. The disagreement between IARC and regulatory evaluations of EFSA/ECHA has received great attention of citizens, organizations and stakeholders, as a result of methodological differences in the evaluation of the available evidence have been identified. This paper outlines the glyphosate controversy, following an overview of the EU EDs Regulation and pesticide legislation.
内分泌干扰物是改变人类和野生动物内分泌系统功能的化合物。大量化学物质已被确定为内分泌干扰物，人类可通过饮食和/或环境暴露（空气、水、土壤）接触到它们。在国际层面，关于内分泌干扰物这一主题的科学讨论聚焦于制定科学标准的问题，据此确定使这些物质成为内分泌干扰物的关键特性。欧盟的监管行动受到了上述讨论的影响，特别是已发布了第2017/2100号法规和第2018/605号法规。然而，这些科学标准并不构成检测内分泌干扰物的完整框架，因此，采用这些标准并不意味着能全面有效地保护人类健康。此外，草甘膦基除草剂（GBH）是全球使用最广泛的农药。草甘膦争议使欧盟的农药监管成为焦点。国际癌症研究机构（IARC）与欧洲食品安全局（EFSA）/欧洲化学品管理局（ECHA）的监管评估之间的分歧受到了公民、组织和利益相关者的极大关注，因为已发现对现有证据进行评估时存在方法上的差异。在概述欧盟内分泌干扰物法规和农药立法之后，本文概述了草甘膦争议。
