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Hydrolysis of several glycol ether acetates and acrylate esters by nasal mucosal carboxylesterase in vitro.鼻腔黏膜羧酸酯酶对几种乙二醇醚醋酸酯和丙烯酸酯的体外水解作用。
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六种常用乙二醇醚的液/气分配系数。

Liquid/air partition coefficients of six commonly used glycol ethers.

作者信息

Johanson G, Dynésius B

机构信息

Division of Work and Environmental Physiology, National Institute of Occupational Health, Solna, Sweden.

出版信息

Br J Ind Med. 1988 Aug;45(8):561-4. doi: 10.1136/oem.45.8.561.

DOI:10.1136/oem.45.8.561
PMID:3415923
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1009652/
Abstract

The toxicokinetics of organic solvents depend largely on their tissue solubilities. Liquid/air partition coefficients (pcs) of six commonly used glycol ethers (2-methoxyethanol (ME), 2-ethoxyethanol (EE), 2-isopropoxyethanol (PE), 2-butoxyethanol (BE), 2-ethoxyethyl acetate (EEA), and 1-methoxy-2-propanol (MP] were determined in vitro using a head space technique. The liquids used were physiological saline, human blood, and olive oil. The pcs were calculated after gas chromatographic quantification of the glycol ethers in the air phase. The water-air pcs ranged from 3800 to 36,000, increasing in the order EEA, BE, MP, PE, EE, ME. These values corresponded closely to the blood/air pcs with one exception--EEA could not be detected in the air phase after addition to blood. The oil/air pcs ranged from 530 to 5400, increasing in the order ME, MP, EE, PE, EEA, BE.

摘要

有机溶剂的毒代动力学在很大程度上取决于它们在组织中的溶解度。使用顶空技术在体外测定了六种常用乙二醇醚（2-甲氧基乙醇（ME）、2-乙氧基乙醇（EE）、2-异丙氧基乙醇（PE）、2-丁氧基乙醇（BE）、2-乙氧基乙酸乙酯（EEA）和1-甲氧基-2-丙醇（MP））的液/气分配系数（pcs）。所使用的液体为生理盐水、人血和橄榄油。通过气相色谱法对气相中的乙二醇醚进行定量后计算pcs。水-气pcs范围为3800至36000，按EEA、BE、MP、PE、EE、ME的顺序增加。这些值与血/气pcs密切对应，只有一个例外——向血液中添加EEA后，在气相中无法检测到EEA。油-气pcs范围为530至5400，按ME、MP、EE、PE、EEA、BE的顺序增加。