Adetifa Ifedayo M O, Uyoga Sophie, Gitonga John N, Mugo Daisy, Otiende Mark, Nyagwange James, Karanja Henry K, Tuju James, Wanjiku Perpetual, Aman Rashid, Mwangangi Mercy, Amoth Patrick, Kasera Kadondi, Ng'ang'a Wangari, Rombo Charles, Yegon Christine, Kithi Khamisi, Odhiambo Elizabeth, Rotich Thomas, Orgut Irene, Kihara Sammy, Bottomley Christian, Kagucia Eunice W, Gallagher Katherine E, Etyang Anthony, Voller Shirine, Lambe Teresa, Wright Daniel, Barasa Edwine, Tsofa Benjamin, Bejon Philip, Ochola-Oyier Lynette I, Agweyu Ambrose, Scott J Anthony G, Warimwe George M
KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom.
Nat Commun. 2021 Jun 25;12(1):3966. doi: 10.1038/s41467-021-24062-3.
Observed SARS-CoV-2 infections and deaths are low in tropical Africa raising questions about the extent of transmission. We measured SARS-CoV-2 IgG by ELISA in 9,922 blood donors across Kenya and adjusted for sampling bias and test performance. By 1st September 2020, 577 COVID-19 deaths were observed nationwide and seroprevalence was 9.1% (95%CI 7.6-10.8%). Seroprevalence in Nairobi was 22.7% (18.0-27.7%). Although most people remained susceptible, SARS-CoV-2 had spread widely in Kenya with apparently low associated mortality.
在热带非洲，观察到的新冠病毒感染和死亡病例数量较低，这引发了关于传播程度的疑问。我们通过酶联免疫吸附测定法（ELISA）对肯尼亚各地9922名献血者的新冠病毒免疫球蛋白G（IgG）进行了检测，并针对抽样偏差和检测性能进行了调整。截至2020年9月1日，全国共观察到577例新冠病毒疾病（COVID-19）死亡病例，血清阳性率为9.1%（95%置信区间7.6 - 10.8%）。内罗毕的血清阳性率为22.7%（18.0 - 27.7%）。尽管大多数人仍易感染，但新冠病毒已在肯尼亚广泛传播，且相关死亡率明显较低。
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