姜烯酮 A，一种存在于生姜中的多酚，可抑制高脂肪饮食喂养的小鼠肥胖和脂肪组织炎症。

Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice.

机构信息

Major in Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.

Department of Food Science and Nutrition, Hallym University, Chuncheon, Republic of Korea.

出版信息

Mol Nutr Food Res. 2017 Oct;61(10). doi: 10.1002/mnfr.201700139. Epub 2017 Jul 20.

SCOPE

Ginger exerts protective effects on obesity and its complications. Our objectives here are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, elucidate the anti-obesity effect of gingerenone A (GA) in diet-induced obesity (DIO), and investigate whether GA affects adipose tissue inflammation (ATI).

METHODS AND RESULTS

Oil red O staining showed that GA had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components tested at a single concentration (40 μM). Consistent with in vitro data, GA attenuates DIO by reducing fat mass in mice. This was accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in vitro and in vivo. Additionally, GA suppressed ATI by inhibiting macrophage recruitment and downregulating pro-inflammatory cytokines.

CONCLUSION

These results suggest that GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation.

范围

姜对肥胖及其并发症具有保护作用。我们的目标是鉴定出能在体外抑制脂肪生成和脂质积累的生物活性化合物，阐明姜烯酮 A（GA）在饮食诱导肥胖（DIO）中的抗肥胖作用，并研究 GA 是否影响脂肪组织炎症（ATI）。

方法和结果

油红 O 染色显示，在测试的姜成分中，GA 在单一浓度（40 μM）下对 3T3-L1 细胞的脂肪生成和脂质积累具有最强的抑制作用。与体外数据一致，GA 通过减少小鼠体内脂肪量来减轻 DIO。这伴随着通过体外和体内激活 AMP 激活的蛋白激酶（AMPK）来调节脂肪酸代谢。此外，GA 通过抑制巨噬细胞募集和下调促炎细胞因子来抑制 ATI。