Wang Juntao, Xu Fang, Zhu Xiaoming, Li Xianghua, Li Yankun, Li Jia
School of Nuclear Technology and Chemistry and Biology, Hubei University of Science and Technology, Xianning, China.
Hubei Key Laboratory of Radiation Chemistry and Functional Materials, Hubei University of Science and Technology, Xianning, China.
Front Bioeng Biotechnol. 2021 Jun 11;9:673415. doi: 10.3389/fbioe.2021.673415. eCollection 2021.
The blood-brain barrier (BBB) is a highly specialized neurovascular unit that protects the brain from potentially harmful substances. In addition, the BBB also engages in the exchange of essential nutrients between the vasculature and brain parenchyma, which is critical for brain homeostasis. Brain diseases, including neurological disorders and cerebrovascular diseases, are often associated with disrupted BBB integrity, evidenced by increased permeability. Therefore, defining the mechanisms underlying the regulation of BBB integrity is crucial for the development of novel therapeutics targeting brain diseases. MicroRNAs (miRNA), a type of small non-coding RNAs, are emerging as an important regulator of BBB integrity. Here we review recent developments related to the role of miRNAs in regulating BBB integrity.
血脑屏障（BBB）是一种高度特化的神经血管单元，可保护大脑免受潜在有害物质的侵害。此外，血脑屏障还参与血管系统与脑实质之间必需营养物质的交换，这对脑内环境稳定至关重要。包括神经疾病和脑血管疾病在内的脑部疾病通常与血脑屏障完整性破坏有关，表现为通透性增加。因此，明确血脑屏障完整性调节的潜在机制对于开发针对脑部疾病的新型疗法至关重要。微小RNA（miRNA）是一类小的非编码RNA，正逐渐成为血脑屏障完整性的重要调节因子。在此，我们综述了与miRNA在调节血脑屏障完整性中的作用相关的最新进展。
