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水飞蓟素和盐生杜氏藻对阿霉素诱导雄性大鼠毒性的抗菌和组织学数据影响。

Antimicrobial and Histological Data Effect of Silybum marianum and Suaeda vermiculata Against Doxorubicin Induced Toxicity in Male Rats.

机构信息

Department of Pharmaceutical Bioproducts Research, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications, New Borg El-Arab City 21934, Alexandria, Egypt.

Department of Nucleic Acid Research, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications, New Borg El-Arab City 21934, Alexandria, Egypt.

出版信息

Asian Pac J Cancer Prev. 2021 Jun 1;22(6):1761-1766. doi: 10.31557/APJCP.2021.22.6.1761.

DOI:10.31557/APJCP.2021.22.6.1761
PMID:34181331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8418846/
Abstract

OBJECTIVE: Silybum marianum and Suaeda vermiculata are popular plants wealthy in cancer prevention agents. There is no enough research on both plants since they are not available in many places. They are widely spread in Egypt. METHODS: This research was performed to estimate their antimicrobial effect as well as their hepatoprotective effect against strong drugs inducing oxidative stress such as doxorubicin which may be a chemotherapeutic operator utilized to treat different sorts of cancer and demonstrated to be hepatotoxic medicate. Six bunches of male Wistar rats were utilized (control, Silybum marianum extricate, Suaeda vermiculata extricate, doxorubicin, Silybum marianum extricate additionally doxorubicin and Suaeda vermiculata extricate additionally doxorubicin). RESULTS: Our data confirmed the effective antimicrobial effect of both plants and also the hepatoprotective effect against oxidative damage. Both plants are highly recommended as natural supplements by patients treated by different drugs inducing oxidative stress whereas; Milk thistle was proved to be stronger hepatoprotective herb.

摘要

目的：水飞蓟和盐角草是富含抗癌成分的流行植物。由于它们在许多地方都没有，因此对这两种植物的研究还不够。它们在埃及广泛分布。

方法：本研究旨在评估它们的抗菌作用以及对强诱导氧化应激药物（如多柔比星）的肝保护作用，多柔比星可能是一种用于治疗各种癌症的化疗药物，并且被证明是一种肝毒性药物。使用了六组雄性 Wistar 大鼠（对照组、水飞蓟提取物、盐角草提取物、多柔比星、水飞蓟提取物加多柔比星和盐角草提取物加多柔比星）。

结果：我们的数据证实了这两种植物具有有效的抗菌作用，并且对氧化损伤具有肝保护作用。这两种植物都被强烈推荐为接受不同诱导氧化应激药物治疗的患者的天然补充剂，而奶蓟草被证明是一种更强的肝保护草药。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/8418846/59210b3a2811/APJCP-22-1761-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/8418846/2c90d9dc9c81/APJCP-22-1761-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/8418846/a9fb3a70ac82/APJCP-22-1761-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/8418846/c6fec35db165/APJCP-22-1761-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/8418846/4d6aedc17ce3/APJCP-22-1761-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/8418846/9fba52e56db4/APJCP-22-1761-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/8418846/5b2c0e6ab2f2/APJCP-22-1761-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/8418846/59210b3a2811/APJCP-22-1761-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/8418846/2c90d9dc9c81/APJCP-22-1761-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/8418846/a9fb3a70ac82/APJCP-22-1761-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/8418846/c6fec35db165/APJCP-22-1761-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/8418846/4d6aedc17ce3/APJCP-22-1761-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/8418846/9fba52e56db4/APJCP-22-1761-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/8418846/5b2c0e6ab2f2/APJCP-22-1761-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f48/8418846/59210b3a2811/APJCP-22-1761-g007.jpg

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[1]
Antimicrobial and Histological Data Effect of Silybum marianum and Suaeda vermiculata Against Doxorubicin Induced Toxicity in Male Rats.

Asian Pac J Cancer Prev. 2021-6-1

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[5]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Comparative biochemical and histopathological evaluations proved that receptacle is the most effective part of Cynara scolymus against liver and kidney damages.

J Ethnopharmacol. 2019-12-4

[2]
Preclinical safety evaluation of the ethanolic extract from guavira fruits (Campomanesia pubescens (D.C.) O. BERG) in experimental models of acute and short-term toxicity in rats.

Food Chem Toxicol. 2018-4-30

[3]
Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases.

Biomed Pharmacother. 2018-4-5

[4]
Taste of phytocompounds: A better predictor for ethnopharmacological activities of medicinal plants than the phytochemical class?

J Ethnopharmacol. 2018-3-29

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Induction of oxidative stress by anticancer drugs in the presence and absence of cells.

Oncol Lett. 2017-11

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A Randomized Trial of Silymarin for the Treatment of Nonalcoholic Steatohepatitis.

Clin Gastroenterol Hepatol. 2017-4-15

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An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL.

Blood. 2016-12-15

[8]
Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

J Diabetes Res. 2016

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Protective effects of the exopolysaccharide Lasiodiplodan against DNA damage and inflammation induced by doxorubicin in rats: Cytogenetic and gene expression assays.

Toxicology. 2017-2-1

[10]
Hepatotoxicity by Drugs: The Most Common Implicated Agents.

Int J Mol Sci. 2016-2-6

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