Department of Pharmacology, Toxicology and Clinical Pharmacology, School of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.
Molecules. 2011 Oct 12;16(10):8601-13. doi: 10.3390/molecules16108601.
Silymarin is a complex of five major compounds, and silibinin is the most biologically active component of the complex. The aim of this study was to investigate, evaluate and confirm the potential cardioprotective and hepatoprotective effects of administration of silymarin, rich in silibinin, at a dose of 60 mg/kg orally for a time-span of 12 days on doxorubicin induced toxicity in male Wistar rats. The in vivo model was used to explore whether silymarin could prevent damage of liver and heart tissue induced by doxorubicin administered every other day at dose of 1.66 mg/kg intraperitoneally for twelve days. In the study the change of body weight, ECG changes, biochemical parameters of oxidative stress, serum activity of alanine and aspartate transaminase, lactate dehydrogenase, creatine kinase and histological preparations of heart and liver samples of treated animals were examined. According to physiological, pharmacological, microscopic and biochemical results, we confirmed that at the examined dose, silymarin exhibits a protective influence on the heart and liver tissue against toxicity induced by doxorubicin.
水飞蓟素是由五种主要化合物组成的复合物，而水飞蓟宾是该复合物中最具生物活性的成分。本研究的目的是研究、评估和确认水飞蓟素（富含水飞蓟宾）以 60mg/kg 剂量口服给药 12 天对雄性 Wistar 大鼠阿霉素诱导毒性的潜在心脏保护和肝脏保护作用。体内模型用于探索水飞蓟素是否可以预防阿霉素（每隔一天腹腔内给予 1.66mg/kg，共 12 天）引起的肝和心脏组织损伤。在研究中，检查了动物体重变化、心电图变化、氧化应激生化参数、血清丙氨酸和天冬氨酸转氨酶、乳酸脱氢酶、肌酸激酶活性以及心脏和肝脏样本的组织学制备。根据生理、药理、显微镜和生化结果，我们证实，在所检查的剂量下，水飞蓟素对心脏和肝脏组织具有抗阿霉素诱导毒性的保护作用。
