日本女性人乳头瘤病毒感染的流行率和危险因素：一项全国范围内的自我采样流行病学调查。
Prevalence and Risk Factors of Human Papillomavirus Infection among Japanese Female People: A Nationwide Epidemiological Survey by Self-Sampling.
机构信息
Japanese Foundation for Sexual Health Medicine, Tokyo, Japan.
Department of Urology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan.
出版信息
Asian Pac J Cancer Prev. 2021 Jun 1;22(6):1843-1849. doi: 10.31557/APJCP.2021.22.6.1843.
BACKGROUND
Nationwide epidemiological surveys of behavioral factors and human papillomavirus (HPV) infection among Japanese women are scarce. This study aimed to determine the prevalence, genotype distribution, and significant predictive factors of HPV infection using self-collected vaginal samples from Japanese female people.
METHODS
The study population consisted of 1,050 female subjects aged 16-75 years (median 30 years). The participants were asked to provide self-collected samples from the vaginal wall using cotton swabs for genotyping of HPV. We compared the participants' characteristics and detected HPV genotypes to determine significant predictors of HPV infection.
RESULTS
After excluding 47 participants (34 participants of unknown age, 11 virgin participants, 1 participant who engaged in sex with another woman, and 1 participant who did not undergo β-globin detection), 1,003 participants were included in the analysis. Of the 1,003 participants, 426 (42.5%) participants had at least one HPV genotype, 282 (28.1%) participants had high-risk HPV genotypes, 306 (30.5%) had low-risk HPV genotypes, and 162 (16.2%) participants had both HPV genotypes. HPV-16/18 positivity was found in 5.4% (54/1,003) participants. The most frequently detected high-risk HPV genotype was HPV-52 (86/1,003; 8.6% participants). The number of lifetime sex partners (≥6) and a present history of sexually transmitted infection (STI) were significant predictors of high-risk HPV infection. The number of lifetime sex partners (≥6), age of coitarche (≥20 years of age), unmarried status, and a present history of STI were significant predictors of low-risk HPV infection.
CONCLUSIONS
The prevalence of high-risk and low-risk HPV infection among Japanese female subjects was 28.1% and 30.5%, respectively. The number of lifetime sex partners (≥6) and present history of sexually transmitted infection were the common significant predictors of high-risk and low-risk HPV infection.
背景
日本女性行为因素和人乳头瘤病毒（HPV）感染的全国性流行病学调查很少。本研究旨在使用日本女性的自我采集阴道样本确定 HPV 感染的流行率、基因型分布和显著预测因素。
方法
研究人群由 1050 名年龄在 16-75 岁（中位数 30 岁）的女性组成。要求参与者使用棉签从阴道壁采集自我采集样本，用于 HPV 基因分型。我们比较了参与者的特征和检测到的 HPV 基因型，以确定 HPV 感染的显著预测因素。
结果
排除 47 名参与者（34 名年龄不明的参与者、11 名处女参与者、1 名与女性发生性关系的参与者和 1 名未进行β-球蛋白检测的参与者）后，1003 名参与者被纳入分析。在 1003 名参与者中，426 名（42.5%）参与者至少有一种 HPV 基因型，282 名（28.1%）参与者有高危 HPV 基因型，306 名（30.5%）参与者有低危 HPV 基因型，162 名（16.2%）参与者同时有 HPV 基因型。1003 名参与者中有 5.4%（54 名）HPV-16/18 阳性。最常检测到的高危 HPV 基因型是 HPV-52（1003 名参与者中的 86 名；8.6%的参与者）。性伴侣数量（≥6 个）和现患性传播感染（STI）史是高危 HPV 感染的显著预测因素。性伴侣数量（≥6 个）、初夜年龄（≥20 岁）、未婚状态和现患 STI 是低危 HPV 感染的显著预测因素。
结论
日本女性高危和低危 HPV 感染的流行率分别为 28.1%和 30.5%。性伴侣数量（≥6 个）和现患性传播感染史是高危和低危 HPV 感染的共同显著预测因素。
Zotero 插件