Universidade Federal de São João del-Rei, Divinópolis, MG, Brazil.
Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Rev Bras Ginecol Obstet. 2021 May;43(5):384-394. doi: 10.1055/s-0041-1729145. Epub 2021 Jun 28.
Coronavirus disease 2019 (COVID-19) is a disease caused by a newly discovered coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which usually leads to non-specific respiratory symptoms. Although pregnant women are considered at risk for respiratory infections by other viruses, such as SARS and Middle East respiratory syndrome (MERS), little is known about their vulnerability to SARS-CoV-2. Therefore, this study aims to identify and present the main studies on the topic, including the postpartum period.
In this narrative review, articles were searched in various databases, organizations, and health entities using keywords compatible with medical subject headings (MeSH), such as: , , , , and .
The review of the scientific literature on the subject revealed that pregnant women with COVID-19 did not present clinical manifestations significantly different from those of non-pregnant women; however, there are contraindicated therapies. Regarding fetuses, studies were identified that reported that infection by SARS-CoV-2 in pregnant women can cause fetal distress, breathing difficulties and premature birth, but there is no substantial evidence of vertical transmission.
Due to the lack of adequate information and the limitations of the analyzed studies, it is necessary to provide detailed clinical data on pregnant women infected with SARS-CoV-2 and on the maternal-fetal repercussions caused by this infection. Thus, this review may contribute to expand the knowledge of professionals working in the area as well as to guide more advanced studies on the risk related to pregnant women and their newborns. Meanwhile, monitoring of confirmed or suspected pregnant women with COVID-19 is essential, including in the postpartum period.
新型冠状病毒病（COVID-19）是由一种新发现的冠状病毒，即严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的疾病，通常导致非特异性呼吸道症状。尽管孕妇被认为易患其他病毒（如 SARS 和中东呼吸综合征（MERS））引起的呼吸道感染，但对她们易感染 SARS-CoV-2 的情况知之甚少。因此，本研究旨在确定并呈现该主题的主要研究，包括产后时期。
在本次叙述性综述中，使用与医学主题词（MeSH）兼容的关键词，在各种数据库、组织和卫生实体中搜索文章，如：、、、、和。
对该主题的科学文献综述表明，患有 COVID-19 的孕妇的临床表现与未怀孕的女性没有显著差异；然而，存在禁忌疗法。至于胎儿，已经发现的研究报告称，孕妇感染 SARS-CoV-2 可导致胎儿窘迫、呼吸困难和早产，但没有确凿的垂直传播证据。
由于缺乏足够的信息和分析研究的局限性，有必要提供有关感染 SARS-CoV-2 的孕妇以及这种感染对母婴的影响的详细临床数据。因此，本次综述可能有助于扩大从事该领域的专业人员的知识，并指导对孕妇及其新生儿相关风险的更深入研究。同时，对确诊或疑似感染 COVID-19 的孕妇进行监测至关重要，包括产后时期。
