Department of Endocrinology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China (mainland).
Department of Endocrinology, Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (mainland).
Med Sci Monit. 2021 Jun 18;27:e930410. doi: 10.12659/MSM.930410.
BACKGROUND Accumulating evidence has shown that serum uric acid and bilirubin are associated with some chronic diseases, owing to their antioxidant capacity, but the previous research produced discrepant results regarding the relation between uric acid, as well as bilirubin, and bone health. This study was designed to assess the relationship of serum uric acid and total bilirubin with bone mineral density and bone turnover markers in men with type 2 diabetes. MATERIAL AND METHODS In total, 631 male patients with type 2 diabetes were included. Data of patients' medical history, biochemical index, bone mineral density of the lumbar vertebra, femoral neck, and total hip, and bone turnover markers including osteocalcin (OC), amino-terminal propeptide of type I procollagen (PINP), type I collagen carboxy-terminal peptide (CTX), and parathyroid hormone were collected and retrospectively analyzed. RESULTS Both serum uric acid and total bilirubin were positively related to bone mineral density of the lumbar vertebra (b=0.179, p.
由于具有抗氧化能力，越来越多的证据表明血清尿酸和胆红素与一些慢性疾病有关，但关于尿酸和胆红素与骨骼健康之间的关系，先前的研究结果存在差异。本研究旨在评估 2 型糖尿病男性患者血清尿酸和总胆红素与骨密度和骨转换标志物的关系。
共纳入 631 例 2 型糖尿病男性患者。收集患者的病史、生化指标、腰椎、股骨颈和全髋关节骨密度以及骨转换标志物，包括骨钙素（OC）、I 型前胶原氨基端前肽（PINP）、I 型胶原羧基端肽（CTX）和甲状旁腺激素，并进行回顾性分析。
血清尿酸和总胆红素均与腰椎骨密度呈正相关（b=0.179，p<0.001）。
