Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi, India.
Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.
Phytother Res. 2021 Oct;35(10):5440-5458. doi: 10.1002/ptr.7176. Epub 2021 Jun 28.
Traditionally, herbal supplements have shown an exceptional potential of desirability for the prevention of diseases and their treatment. Sulforaphane (SFN), an organosulfur compound belongs to the isothiocyanate (ITC) group and is mainly found naturally in cruciferous vegetables. Several studies have now revealed that SFN possesses broad spectrum of activities and has shown extraordinary potential as antioxidant, antitumor, anti-angiogenic, and anti-inflammatory agent. In addition, SFN is proven to be less toxic, non-oxidizable, and its administration to individuals is well tolerated, making it an effective natural dietary supplement for clinical trials. SFN has shown its ability to be a promising future drug molecule for the management of various diseases mainly due to its potent antioxidant properties. In recent times, several newer drug delivery systems were designed and developed for this potential molecule in order to enhance its bioavailability, stability, and to reduce its side effects. This review focuses to cover numerous data supporting the wide range of pharmacological activities of SFN, its drug-related issues, and approaches to improve its physicochemical and biological properties, including solubility, stability, and bioavailability. Recent patents and the ongoing clinical trials on SFN are also summarized.
传统上，草药补充剂在预防疾病和治疗疾病方面表现出了非凡的可取性潜力。萝卜硫素（SFN）是一种有机硫化合物，属于异硫氰酸酯（ITC）类，主要存在于十字花科蔬菜中。现在有几项研究表明，SFN 具有广泛的活性，具有作为抗氧化剂、抗肿瘤、抗血管生成和抗炎剂的非凡潜力。此外，SFN 被证明毒性较小，不易氧化，且个体服用后耐受性良好，使其成为临床试验中有效的天然膳食补充剂。SFN 因其强大的抗氧化特性而显示出成为有前途的未来药物分子的能力，主要用于治疗各种疾病。最近，为了提高其生物利用度、稳定性并降低其副作用，设计并开发了几种新型药物传递系统来传递这种潜在分子。本综述重点介绍了支持 SFN 的广泛药理活性、其与药物相关的问题以及改善其物理化学和生物学特性的方法的大量数据，包括溶解度、稳定性和生物利用度。还总结了 SFN 的最新专利和正在进行的临床试验。
