Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir, Turkey; Izmir Biomedicine and Genome Institute, Dokuz Eylul University Health Campus, Izmir, Turkey.
Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir, Turkey.
Mol Immunol. 2021 Dec;140:175-185. doi: 10.1016/j.molimm.2021.10.014. Epub 2021 Oct 28.
SFN, a dietary phytochemical, is a significant member of isothiocyanates present in cruciferous vegetables at high levels in broccoli. It is a well-known activator of the Nrf2/ARE antioxidant pathway. Long since, the therapeutic effects of SFN have been widely studied in several different diseases. Other than the antioxidant effect, SFN also exhibits an anti-inflammatory effect through suppression of various mechanisms, including inflammasome activation. Considerably, SFN has been demonstrated to inhibit multiple inflammasomes, including NLRP3 inflammasome. NLRP3 inflammasome induces secretion of pro-inflammatory cytokines and promotes inflammatory cell death. The release of pro-inflammatory cytokines enhances the inflammatory response, in turn leading to tissue damage. These self-propelling inflammatory responses would need modulation with exogenous therapeutic agents to suppress them. SFN is a promising candidate molecule for the mitigation of NLRP3 inflammasome activation, which has been related to the pathogenesis of numerous disorders. In this review, we have provided fundamental knowledge about Sulforaphane, elaborated its characteristics, and evidentially focused on its mechanisms of action with regard to its anti-inflammatory, anti-oxidative, and neuroprotective features. Thereafter, we have summarized both in vitro and in vivo studies regarding SFN effect on NLRP3 inflammasome activation.
SFN，一种膳食植物化学物质，是十字花科蔬菜中高水平存在的异硫氰酸盐的重要成员。它是 Nrf2/ARE 抗氧化途径的著名激活剂。SFN 的治疗效果早已在多种不同疾病中得到广泛研究。除了抗氧化作用外，SFN 还通过抑制多种机制，包括炎症小体激活，表现出抗炎作用。值得注意的是，SFN 已被证明可以抑制多种炎症小体，包括 NLRP3 炎症小体。NLRP3 炎症小体诱导促炎细胞因子的分泌，并促进炎症细胞死亡。促炎细胞因子的释放增强了炎症反应，进而导致组织损伤。这些自我推动的炎症反应需要用外源性治疗剂来调节以抑制它们。SFN 是一种有前途的候选分子，可减轻 NLRP3 炎症小体的激活，这与许多疾病的发病机制有关。在这篇综述中，我们提供了关于 Sulforaphane 的基础知识，阐述了它的特点，并着重阐述了其抗炎、抗氧化和神经保护作用的作用机制。之后，我们总结了 SFN 对 NLRP3 炎症小体激活的体外和体内研究。
