系统发育基因组学揭示了新冠病毒多次传入秘鲁并早期传播的情况。
Phylogenomics reveals multiple introductions and early spread of SARS-CoV-2 into Peru.
作者信息
Juscamayta-López Eduardo, Carhuaricra Dennis, Tarazona David, Valdivia Faviola, Rojas Nancy, Maturrano Lenin, Gavilán Ronnie
机构信息
Laboratorio de Infecciones Respiratorias Agudas, Centro Nacional de Salud Pública, Instituto Nacional de Salud, Lima, Peru.
Laboratorio de Biología y Genética Molecular, Universidad Nacional Mayor de San Marcos, Lima, Peru.
出版信息
J Med Virol. 2021 Oct;93(10):5961-5968. doi: 10.1002/jmv.27167. Epub 2021 Jul 16.
Abstract
Peru has become one of the countries with the highest mortality rates from the current coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To investigate early transmission events and the genomic diversity of SARS-CoV-2 isolates circulating in Peru in the early COVID-19 pandemic, we analyzed 3472 viral genomes, of which 149 were from Peru. Phylogenomic analysis revealed multiple and independent introductions of the virus likely from Europe and Asia and a high diversity of genetic lineages circulating in Peru. In addition, we found evidence for community-driven transmission of SARS-CoV-2 as suggested by clusters of related viruses found in patients living in different regions of Peru.
摘要
秘鲁已成为因严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发的2019年新型冠状病毒病（COVID-19）大流行而死亡率最高的国家之一。为调查COVID-19大流行早期在秘鲁传播的SARS-CoV-2毒株的早期传播事件及基因组多样性情况，我们分析了3472个病毒基因组，其中149个来自秘鲁。系统基因组学分析显示，该病毒可能有多次且独立地从欧洲和亚洲传入，并且在秘鲁流行的遗传谱系具有高度多样性。此外，正如在秘鲁不同地区居住的患者中发现的相关病毒簇所表明的那样，我们发现了SARS-CoV-2由社区驱动传播的证据。
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