Institute of Marine Biology and Pharmacology, Ocean College, Zhejiang University, Zhoushan, People's Republic of China.
Nat Prod Res. 2021 Jul;35(13):2117-2122. doi: 10.1080/14786419.2019.1660336. Epub 2019 Sep 6.
Gephyyamycin () owned the rare 3,12a-epoxybenz[]anthracene ring system, and cysrabelomycin () possessed an acetylated cysteine group, two new angucyclinone derivatives were isolated from the rice solid fermentation of the marine-derived sp. HN-A124, an actinobacterium isolated from the marine sediments collected from Hainan Province, China. Their structures were elucidated on the basis of MS, NMR spectroscopic, X-ray diffration data analyses and quantum chemical calculations of the electronic circular dichroism (ECD) spectra. Compound appeared to show moderate cytotoxicity against human prostate cancer PC3 and human ovarian carcinoma A2780 cell lines with IC values of 19.39 and 10.23 μM, respectively; on the other hand, compound also exhibited moderate antibacterial activities against and with an MIC value of 20.0 and 20 μM, respectively.
吉菲霉素（）拥有罕见的 3,12a-环氧苯[]蒽环系统，而 cysrabelomycin（）则含有乙酰化半胱氨酸基团。从中国海南省海洋沉积物中分离得到的海洋来源放线菌 HN-A124 的大米固体发酵中分离得到了两种新型的蒽环酮衍生物。基于 MS、NMR 光谱、X 射线衍射数据分析和电子圆二色谱（ECD）光谱的量子化学计算，解析了它们的结构。化合物对人前列腺癌细胞 PC3 和人卵巢癌细胞 A2780 表现出中等的细胞毒性，IC 值分别为 19.39 和 10.23 μM；另一方面，化合物对和也表现出中等的抗菌活性，MIC 值分别为 20.0 和 20 μM。
