Division of Epidemiology and Biostatistics, Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, GA, 30303, USA.
Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA, USA.
BMC Res Notes. 2021 Jun 30;14(1):252. doi: 10.1186/s13104-021-05662-0.
The purpose of this study is to compare the prevalence of latent TB infection (LTBI) among patients with type-2 diabetes mellitus (T2DM) to healthy controls without T2DM. To achieve this objective, we conducted a case-control study in a large hospital in Atlanta from 2016 to 2019.
We enrolled 98 cases; 119 potential controls were screened, 84 of which had HbA1c ≥ 5.7% and one did not have QFT result, leaving 34 (28.6%) individuals enrolled as controls. LTBI prevalence was 9.2% among cases and 14.7% among controls (crude odds ratio 0.59, 95% CI 0.19-2.04). After adjusting for age and sex, the adjusted odds of LTBI among patients with T2DM was 0.45 (95% CI 0.13, 1.71) times the controls. We did not observe a statistically significant association between LTBI and T2DM. However, we reported a positive correlation between HbA1c level and nil count among individuals with LTBI (R = 0.55, p < 0.01). In addition, we reported a high prevalence of LTBI among adults with T2DM and family members without T2DM.
本研究旨在比较 2 型糖尿病（T2DM）患者与无 T2DM 的健康对照者之间潜伏性结核感染（LTBI）的患病率。为了实现这一目标，我们于 2016 年至 2019 年在亚特兰大的一家大医院进行了一项病例对照研究。
我们纳入了 98 例病例；筛查了 119 名潜在对照者，其中 84 名 HbA1c≥5.7%，1 名未进行 QFT 结果检测，最终纳入 34 名（28.6%）对照者。病例组的 LTBI 患病率为 9.2%，对照组为 14.7%（粗比值比 0.59，95%CI 0.19-2.04）。调整年龄和性别后，T2DM 患者的 LTBI 调整比值比为 0.45（95%CI 0.13-1.71）。我们未观察到 LTBI 与 T2DM 之间存在统计学显著关联。然而，我们报告了 LTBI 个体中 HbA1c 水平与 QFT 阴性计数之间存在正相关（R=0.55，p<0.01）。此外，我们报告了 T2DM 成人及其无 T2DM 的家庭成员中 LTBI 的高患病率。
