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情感性疾病中血小板对14C-5-羟色胺的摄取与释放

Uptake and release of 14 C-5-hydroxytryptamine by platelets in affective illness.

作者信息

Shaw D M, MacSweeney D A, Woolcock N, Bevan-Jones A B

出版信息

J Neurol Neurosurg Psychiatry. 1971 Jun;34(3):224-5. doi: 10.1136/jnnp.34.3.224.

Abstract

In the search for paradigms of postulated abnormalities in indolamine function in the brain in affective disorders, 5-HT uptake and release was estimated in platelets from patients suffering from severe depressive illness. Neither of these measures was altered by the illness and the most likely explanation for the negative findings was that in this setting platelets are not a suitable model.

摘要

在寻找情感障碍中大脑吲哚胺功能假定异常的范例时,对重度抑郁症患者血小板中的5-羟色胺摄取和释放进行了评估。这两项测量结果均未因疾病而改变,对于这些阴性结果最可能的解释是,在这种情况下血小板并非合适的模型。

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引用本文的文献

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Biochemical assessment of antidepressive drugs.抗抑郁药物的生化评估。
Br J Clin Pharmacol. 1980 Dec;10(6):539-50. doi: 10.1111/j.1365-2125.1980.tb00508.x.

本文引用的文献

1
Tryptamine metabolism in depression.抑郁症中的色胺代谢
Br J Psychiatry. 1965 Oct;111(479):993-8. doi: 10.1192/bjp.111.479.993.
2
Metabolism, transfer and storage of 5-hydroxytryptamine in blood platelets.5-羟色胺在血小板中的代谢、转运与储存
Br J Pharmacol Chemother. 1968 Jan;32(1):1-16. doi: 10.1111/j.1476-5381.1968.tb00423.x.

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