Deakin M, Colin-Jones D G, Vessey M P
Department of Gastroenterology, Queen Alexandra Hospital, Cosham, Portsmouth, UK.
Postgrad Med J. 1988 Jan;64(747):33-7. doi: 10.1136/pgmj.64.747.33.
If the poor prognosis for patients with adenocarcinoma of the stomach is to be improved, it is important to make the diagnosis at an early stage. In order to evaluate our routine diagnostic practice, we have performed a retrospective study of patients in the Portsmouth and Oxford Health Districts who were diagnosed as having adenocarcinoma of the stomach during 1979 and 1980. Three hundred and forty-two patients were identified; the great majority had advanced disease at the first presentation. Only 9 patients (2.6%) were identified as having early gastric carcinoma and a total of 46 patients (13.4%) had either Stage 1 or 2 disease. Despite the provision of an endoscopy service, gastric carcinoma is still being diagnosed at an advanced stage. Initial false negative investigations caused a delay in diagnosis in 18.4% of patients. During the year preceding diagnosis (when tumour was likely to have been present), the false negative rate for barium meal examination was 25.5% and for endoscopy 13.5%. Negative results should not deter us from pursuing the diagnosis of tumour in those patients with persisting symptoms.
若要改善胃癌患者的不良预后,早期诊断至关重要。为评估我们的常规诊断实践,我们对朴茨茅斯和牛津健康区在1979年至1980年期间被诊断为胃癌的患者进行了一项回顾性研究。共识别出342例患者;绝大多数患者初诊时已处于疾病晚期。仅9例患者(2.6%)被诊断为早期胃癌,共有46例患者(13.4%)处于1期或2期疾病。尽管提供了内镜检查服务,但胃癌仍在晚期才被诊断出来。最初的假阴性检查导致18.4%的患者诊断延迟。在诊断前的一年(此时肿瘤可能已经存在),钡餐检查的假阴性率为25.5%,内镜检查为13.5%。阴性结果不应阻止我们对那些持续有症状的患者进行肿瘤诊断。