Institute for Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
Department of Statistics and Probability, Michigan State University, East Lansing, MI 48864, USA.
Int J Environ Res Public Health. 2021 Jun 8;18(12):6215. doi: 10.3390/ijerph18126215.
Resettlers are a large migrant group of more than 2 million people in Germany who migrated mainly from the former Soviet Union to Germany after 1989. We sought to compare the distribution of the major risk factors for cardiovascular disease (CVD) and to investigate the overall genetic differences in a study population which consisted of resettlers and native (autochthone) Germans. This was a joint analysis of two cohort studies which were performed in the region of Augsburg, Bavaria, Germany, with 3363 native Germans and 363 resettlers. Data from questionnaires and physical examinations were used to compare the risk factors for cardiovascular diseases between the resettlers and native Germans. A population-based genome-wide association analysis was performed in order to identify the genetic differences between the two groups. The distribution of the major risk factors for CVD differed between the two groups. The resettlers lead a less active lifestyle. While female resettlers smoked less than their German counterparts, the men showed similar smoking behavior. SNPs from three genes (BTNL2, DGKB, TGFBR3) indicated a difference in the two populations. In other studies, these genes have been shown to be associated with CVD, rheumatoid arthritis and osteoporosis, respectively.
移居者是德国一个超过 200 万的大型移民群体，他们主要在 1989 年后从前苏联移居到德国。我们试图比较移居者和本土（土生土长的）德国人这两个群体之间心血管疾病（CVD）的主要危险因素的分布情况，并调查整体遗传差异。这是在德国巴伐利亚州奥格斯堡地区进行的两项队列研究的联合分析，研究对象包括 3363 名本土德国人及 363 名移居者。我们利用问卷调查和体检数据来比较移居者和本土德国人的心血管疾病风险因素。为了确定两组人群之间的遗传差异，我们进行了基于人群的全基因组关联分析。两组人群的 CVD 主要危险因素分布存在差异。移居者的生活方式不那么活跃。虽然女性移居者的吸烟量少于德国女性，但男性的吸烟行为相似。来自三个基因（BTNL2、DGKB、TGFBR3）的 SNP 表明两组人群存在差异。在其他研究中，这些基因分别与 CVD、类风湿关节炎和骨质疏松症有关。
