神经酰胺代谢与帕金森病——治疗靶点
Ceramide Metabolism and Parkinson's Disease-Therapeutic Targets.
作者信息
Custodia Antía, Aramburu-Núñez Marta, Correa-Paz Clara, Posado-Fernández Adrián, Gómez-Larrauri Ana, Castillo José, Gómez-Muñoz Antonio, Sobrino Tomás, Ouro Alberto
机构信息
Clinical Neurosciences Research Laboratories, Health Research Institute of Santiago de Compostela (IDIS), Travesa da Choupana s/n, 15706 Santiago de Compostela, Spain.
Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country, P.O. Box 644, 48980 Bilbao, Spain.
出版信息
Biomolecules. 2021 Jun 25;11(7):945. doi: 10.3390/biom11070945.
Ceramide is a bioactive sphingolipid involved in numerous cellular processes. In addition to being the precursor of complex sphingolipids, ceramides can act as second messengers, especially when they are generated at the plasma membrane of cells. Its metabolic dysfunction may lead to or be a consequence of an underlying disease. Recent reports on transcriptomics and electrospray ionization mass spectrometry analysis have demonstrated the variation of specific levels of sphingolipids and enzymes involved in their metabolism in different neurodegenerative diseases. In the present review, we highlight the most relevant discoveries related to ceramide and neurodegeneration, with a special focus on Parkinson's disease.
神经酰胺是一种参与众多细胞过程的生物活性鞘脂。除了作为复杂鞘脂的前体，神经酰胺还可充当第二信使，尤其是当它们在细胞膜上生成时。其代谢功能障碍可能导致潜在疾病或为潜在疾病的结果。最近关于转录组学和电喷雾电离质谱分析的报告表明，在不同神经退行性疾病中，参与鞘脂代谢的特定鞘脂和酶水平存在差异。在本综述中，我们重点介绍了与神经酰胺和神经退行性变相关的最相关发现，特别关注帕金森病。
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