Walawska-Hrycek Anna, Galus Weronika, Hrycek Eugeniusz, Kaczmarczyk Aleksandra, Krzystanek Ewa
Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Department of Cardiology, Faculty of Medical Sciences, Andrzej Frycz Modrzewski Krakow University, 30-705 Krakow, Poland.
J Clin Med. 2021 Jun 24;10(13):2781. doi: 10.3390/jcm10132781.
Vitamin D is known to have immunomodulatory properties and its deficiency is identified as an environmental risk factor for the development of autoimmune diseases, including multiple sclerosis. The aim of this study was to assess whether low-dose vitamin D supplementation could normalize the 25(OH)D serum levels in patients with relapsing-remitting multiple sclerosis (RRMS) and vitamin D deficiency (serum 25(OH)D < 75 nmol/L), and whether it may impact serum levels of selected cytokines. Among 44 patients (mean age 38.4 ± 10.1 years, 33 women and 11 men), after 12 months of low-dose vitamin D supplementation, serum levels of 25(OH)D normalized in 34 (77.3%) of the patients. Together with vitamin D increase, median levels of anti-inflammatory cytokines (IL10, TGF-β) and regulatory IFN-γ increased, while proinflammatory IL-17 remained unchanged. Moreover, an increase of inorganic phosphorus levels and decrease of PTH levels were observed, but without changes in total calcium concentration. These results may indicate that long-term supplementation with low doses of vitamin D is sufficient to compensate its deficiency in patients with RRMS and may help to maintain beneficial anti-inflammatory cytokine profile.
众所周知，维生素D具有免疫调节特性，其缺乏被认为是包括多发性硬化症在内的自身免疫性疾病发生的环境风险因素。本研究的目的是评估低剂量补充维生素D是否能使复发缓解型多发性硬化症（RRMS）和维生素D缺乏（血清25(OH)D < 75 nmol/L）患者的血清25(OH)D水平正常化，以及它是否可能影响所选细胞因子的血清水平。在44例患者（平均年龄38.4 ± 10.1岁，33名女性和11名男性）中，低剂量补充维生素D 12个月后，34例（77.3%）患者的血清25(OH)D水平恢复正常。随着维生素D水平升高，抗炎细胞因子（IL10、TGF-β）和调节性IFN-γ的中位数水平升高，而促炎细胞因子IL-17保持不变。此外，观察到无机磷水平升高和甲状旁腺激素水平降低，但总钙浓度无变化。这些结果可能表明，长期低剂量补充维生素D足以弥补RRMS患者的维生素D缺乏，并可能有助于维持有益的抗炎细胞因子谱。
