Bressler N M, Bressler S B, Seddon J M, Gragoudas E S, Jacobson L P
Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Retina. 1988;8(2):109-14. doi: 10.1097/00006982-198808020-00005.
The drusen characteristics of 38 eyes from 38 patients with bilateral drusen associated with age-related macular degeneration (AMD) were compared in a masked fashion to 89 fellow eyes from 89 patients with unilateral exudative AMD (disciform scarring or choroidal neovascularization). The average age of the drusen group (67.4 years) was significantly less (P = 0.01) than the average age of the unilateral exudative group (72.6 years). Multiple logistic regression was used to compare the drusen characteristics in the two groups, controlling for the age and sex of the patients. Among patients 75 years of age and younger, patients with confluent drusen had an increased risk of having a fellow eye with exudative AMD compared with patients without confluent drusen. Among patients older than 75 years of age, confluent drusen did not significantly differentiate the two study groups, although confluent drusen in this older age group were more often associated with the bilateral drusen group. Focal hyperpigmentation of the retinal pigment epithelium was also associated with the unilateral exudative group. These drusen characteristics should be evaluated in future prospective studies designed to determine which eyes with drusen are at greatest risk for developing the blinding complications of choroidal neovascularization.
以盲法比较了38例双侧玻璃膜疣伴年龄相关性黄斑变性（AMD）患者的38只眼的玻璃膜疣特征与89例单侧渗出性AMD（盘状瘢痕或脉络膜新生血管）患者的89只对侧眼。玻璃膜疣组的平均年龄（67.4岁）显著低于单侧渗出性组的平均年龄（72.6岁）（P = 0.01）。采用多因素logistic回归比较两组的玻璃膜疣特征，并对患者的年龄和性别进行校正。在75岁及以下的患者中，与无融合性玻璃膜疣的患者相比，有融合性玻璃膜疣的患者其对侧眼发生渗出性AMD的风险增加。在75岁以上的患者中，尽管该年龄组的融合性玻璃膜疣更常与双侧玻璃膜疣组相关，但融合性玻璃膜疣并不能显著区分两个研究组。视网膜色素上皮的局灶性色素沉着也与单侧渗出性组相关。在未来旨在确定哪些有玻璃膜疣的眼发生脉络膜新生血管致盲并发症风险最高的前瞻性研究中，应评估这些玻璃膜疣特征。
