Fernández-Fernández Leandro, Barquilla-García Alfonso, Sánchez-Vega Javier, Risco-Solanilla José Carlos, Suárez-González Félix, Buitrago Francisco
Servicio Extremeño de Salud, Centro de Salud de Zafra, 06300 Badajoz, Spain.
Servicio Extremeño de Salud, Centro de Salud de Trujillo, 10200 Cáceres, Spain.
J Clin Med. 2021 Jun 29;10(13):2886. doi: 10.3390/jcm10132886.
Diabetes mellitus (DM) is one of the leading causes of chronic kidney disease (CKD). We analyzed the prevalence of CKD in the population with diabetes in Extremadura (Spain). retrospective observational study was carried in the diabetic population attended in the Extremadura Health System in 2012-2014. A total of 38,253 patients, ≥18 years old were included. Estimated glomerular filtration rate (eGFR) was calculated using the CKD Epidemiology Collaboration equation. CKD was defined as follow: an eGFR <60 mL/min/1.73 m in a time period ≥ of three months or the presence of renal damage, with or without reduced eGFR, if the urine albumin-creatinine ratio (UACR) was ≥30 mg/g, also in a time period ≥ of three months. The prevalence rate of CKD was 25.3% (27.6% in women; 23.0% in men) and increases with age (34.0% in ≥65 years-olds). 24.9% of patients with CKD were in the very-high risk category for cardiovascular events (6.3% of the diabetic population). If CKD were diagnosed without requiring sustained eGFR <60 mL/min/1.73 m and/or sustained UACR ≥30 mg/g (as it is frequently found in the literature) this would overestimate the prevalence of CKD by 23%.
糖尿病（DM）是慢性肾脏病（CKD）的主要病因之一。我们分析了西班牙埃斯特雷马杜拉糖尿病患者人群中CKD的患病率。对2012年至2014年在埃斯特雷马杜拉卫生系统就诊的糖尿病患者进行了回顾性观察研究。共纳入38253名年龄≥18岁的患者。使用CKD流行病学协作组方程计算估计肾小球滤过率（eGFR）。CKD的定义如下：在至少三个月的时间段内eGFR<60 mL/min/1.73 m²，或存在肾脏损伤，无论eGFR是否降低，若尿白蛋白肌酐比值（UACR）≥30 mg/g，同样在至少三个月的时间段内。CKD的患病率为25.3%（女性为27.6%；男性为23.0%），且随年龄增长而增加（≥65岁人群中为34.0%）。24.9%的CKD患者属于心血管事件极高风险类别（占糖尿病患者人群的6.3%）。如果在诊断CKD时不需要持续的eGFR<60 mL/min/1.73 m²和/或持续的UACR≥30 mg/g（正如文献中经常发现的那样），这将使CKD的患病率高估23%。
