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新型负载光热转化剂和化疗药物的聚乙烯醇基微球用于结直肠癌治疗

Novel PVA-Based Microspheres Co-Loaded with Photothermal Transforming Agent and Chemotherapeutic for Colorectal Cancer Treatment.

作者信息

Zhang Yao, He Zirui, Yang Fan, Ye Changqing, Xu Xia, Wang Shige, Zhang Ling, Zou Duowu

机构信息

Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No.197, Rui Jin Er Road, Shanghai 200025, China.

Department of General Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No.197, Rui Jin Er Road, Shanghai 200025, China.

出版信息

Pharmaceutics. 2021 Jun 29;13(7):984. doi: 10.3390/pharmaceutics13070984.

DOI:10.3390/pharmaceutics13070984
PMID:34209684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8309159/
Abstract

BACKGROUND

We previously designed an electrospinning chitosan (CS) nanofiber-based carrier, using polyvinyl alcohol (PVA) as an adjuvant to deliver doxorubicin (DOX) and MoS nanosheets for postoperative tumor re-occurrence inhibition. However, owing to that the nanofibrous mat is un-injectable, this composite nanofiber is far from being clinically applicable.

MATERIALS AND METHODS

Via modulating the electrospray parameters, polyvinyl alcohol (PVA) beads string doped with DOX and MoS (PVA/MoS/DOX microspheres) were prepared, which were further crosslinked with glutaraldehyde to obtain the water-stability.

RESULTS

Under the 808-nm laser irradiation, MoS nanosheets rendered the prepared PVA/MoS/DOX microspheres an excellent light-to-heat conversion performance with η of 23.2%. Besides, the heat generated by near-infrared laser irradiation can improve the effect of chemotherapy by promoting the release rate of DOX. HT29 cell and tumor-bearing nude mice were used to systematically study the combined tumor treatment efficiency of composite nanospheres.

CONCLUSION

PVA/MoS/DOX nanospheres have excellent photothermal effect and chemotherapy effect, which can completely suppress the tumor recurrence. Therefore, the PVA/MoS/DOX nanospheres are anticipated to find potential applications in the treatment of local colorectal cancer.

摘要

背景

我们之前设计了一种基于静电纺丝壳聚糖（CS）纳米纤维的载体，使用聚乙烯醇（PVA）作为佐剂来递送阿霉素（DOX）和二硫化钼（MoS）纳米片以抑制术后肿瘤复发。然而，由于纳米纤维垫不可注射，这种复合纳米纤维远未达到临床应用的要求。

材料与方法

通过调节电喷雾参数，制备了掺杂DOX和MoS的聚乙烯醇（PVA）串珠（PVA/MoS/DOX微球），并进一步用戊二醛交联以获得水稳定性。

结果

在808纳米激光照射下，MoS纳米片使制备的PVA/MoS/DOX微球具有出色的光热转换性能，转换效率η为23.2%。此外，近红外激光照射产生的热量可通过提高DOX的释放速率来增强化疗效果。利用HT29细胞和荷瘤裸鼠系统地研究了复合纳米球联合治疗肿瘤的效果。

结论

PVA/MoS/DOX纳米球具有出色的光热效应和化疗效果，可完全抑制肿瘤复发。因此，预计PVA/MoS/DOX纳米球在局部结直肠癌治疗中具有潜在应用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/1b6a4de9921d/pharmaceutics-13-00984-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/086b5c6123e4/pharmaceutics-13-00984-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/9a10ee0f2a25/pharmaceutics-13-00984-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/78127e04b867/pharmaceutics-13-00984-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/2a66d478c6c1/pharmaceutics-13-00984-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/8fa1ced8bbf7/pharmaceutics-13-00984-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/92509c376570/pharmaceutics-13-00984-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/9b6ab12e6127/pharmaceutics-13-00984-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/b6a27bfdf3eb/pharmaceutics-13-00984-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/1b6a4de9921d/pharmaceutics-13-00984-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/086b5c6123e4/pharmaceutics-13-00984-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/9a10ee0f2a25/pharmaceutics-13-00984-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/78127e04b867/pharmaceutics-13-00984-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/2a66d478c6c1/pharmaceutics-13-00984-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/8fa1ced8bbf7/pharmaceutics-13-00984-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/92509c376570/pharmaceutics-13-00984-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/9b6ab12e6127/pharmaceutics-13-00984-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/b6a27bfdf3eb/pharmaceutics-13-00984-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72f7/8309159/1b6a4de9921d/pharmaceutics-13-00984-g008.jpg

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