Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA; Duke Clinical Research Institute, Durham, North Carolina, USA.
Department of Medicine, University of Arkansas for Medical Sciences, Arkansas, USA.
J Am Coll Cardiol. 2021 Jul 6;78(1):66-76. doi: 10.1016/j.jacc.2021.04.090.
The lymphatic system is an integral part of the circulatory system and plays an important role in the volume homeostasis of the human body. The complex anatomy and physiology paired with a lack of simple diagnostic tools to study the lymphatic system have led to an underappreciation of the contribution of the lymphatic system to acute and chronic heart failure (HF). Herein, we discuss the physiological role of the lymphatic system in volume management and the evidence demonstrating the dysregulation of the lymphatic system in HF. Further, we discuss the opportunity to target the lymphatic system in the management of HF and different potential approaches to accessing the lymphatic system.
淋巴系统是循环系统的一个组成部分，在人体的容量平衡中起着重要作用。复杂的解剖结构和生理学，再加上缺乏简单的诊断工具来研究淋巴系统，导致人们对淋巴系统在急性和慢性心力衰竭（HF）中的作用认识不足。在此，我们讨论了淋巴系统在容量管理中的生理作用，并讨论了证明 HF 中淋巴系统失调的证据。此外，我们还讨论了在 HF 管理中靶向淋巴系统的机会以及不同的潜在方法来接近淋巴系统。
