CIRIMAT, Université de Toulouse, CNRS, Université Toulouse 3 Paul Sabatier, ENSIACET, Toulouse, 31030, France.
Intitut Claudius Regaud, IUCT-Oncopole, Toulouse, 31059, France.
Future Oncol. 2021 Sep;17(26):3511-3528. doi: 10.2217/fon-2021-0128. Epub 2021 Jul 2.
Osteosarcoma represents the second most common cause of death in children and young adults. No biomaterial allowing local drug delivery has been specifically developed. However, a biocompatible bioactive implantable material could prevent some amputations, and the local release of an antitumor agent could limit risks of relapse and metastasis. We propose a proof of concept of a self-setting paste combining amorphous calcium phosphate and doxorubicin-loaded particles of bone-like carbonated nanocrystalline apatite, as a means of local release. The cement formulation and doping, first with folic acid and then with doxorubicin, was successful. Its physicochemistry was scrutinized. Preliminary data on an invasive osteosarcoma rat model suggest a limiting effect on metastatic events in the lungs without signs of toxicity.
骨肉瘤是儿童和青年人群中第二大常见的致死原因。目前尚未专门开发出任何能够实现局部药物递送的生物材料。然而，生物相容性的生物活性植入材料可以预防一些截肢手术，局部释放抗肿瘤药物可以降低复发和转移的风险。我们提出了一种自凝糊剂的概念验证，该糊剂由无定形磷酸钙和载有骨样碳酸纳米晶磷灰石的阿霉素颗粒组成，作为局部释放的一种手段。水泥配方和掺杂，首先是叶酸，然后是阿霉素，都取得了成功。对其物理化学性质进行了详细研究。初步的骨肉瘤大鼠模型数据表明，该糊剂可在不产生毒性的情况下，对肺部转移事件产生限制作用。
