Bishop N H, Miller J N
J Immunol. 1976 Jul;117(1):191-6.
Evidence of a role for human factor(s) in immunity to experimental syphilis has been provided by the demonstration that passive immunization of rabbits by daily i.v. injections of immune serum significantly delays the appearance and markedly diminishes the severity and duration of lesions which develop after challenge with Treponema pallidum. Five rabbits were injected daily over 37 days with 3 ml/kg body weight of pooled immune rabbit serum injection with 1.1 X 10(3) T. pallidum, Nichols strain, at each of four sites. The animals developed atypical lesions of short duration after an average delay in onset of 28 days short duration after an average delay in onset of 28 days beyond the development of typical lesions in control animals similarly injected with nonimmune serum or saline. The failure of passive immunization to provide complete protection was evident not only in the development of the atypical lesions, but also in the demonstration of disseminated infection in the tissues of three of the four surviving animals 7 months after challenge. The possibility that incomplete protection may have been due to 1) insufficient immune serum levels, 2) intracellular location of T. pallidum, and/or 3) cell-mediated mechanisms is discussed.
通过以下证明，已提供了人类因素在实验性梅毒免疫中起作用的证据：每天静脉注射免疫血清对兔子进行被动免疫，可显著延迟病变的出现，并明显减轻在用梅毒螺旋体攻击后出现的病变的严重程度和持续时间。五只兔子在37天内每天注射3 ml/kg体重的混合免疫兔血清，在四个部位各注射1.1×10³梅毒螺旋体Nichols株。与同样注射非免疫血清或盐水的对照动物相比，这些动物在平均延迟28天发病后出现了持续时间短的非典型病变。被动免疫未能提供完全保护，这不仅体现在非典型病变的出现上，还体现在四只存活动物中有三只在攻击后7个月的组织中出现了播散性感染。文中讨论了不完全保护可能是由于1）免疫血清水平不足、2）梅毒螺旋体的细胞内定位和/或3）细胞介导机制的可能性。
