Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Alberta Health Services, Calgary, Alberta, Canada.
Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Cancer Res. 2021 Oct 1;81(19):4889-4895. doi: 10.1158/0008-5472.CAN-21-1258. Epub 2021 Jul 2.
We systematically reviewed and synthesized evidence on the impact of physical activity/exercise on cancer treatment efficacy. We included six preclinical and seven clinical studies. Exercise significantly enhanced the efficacy of chemotherapy and tamoxifen in seven of eight rodent models in either an additive, sensitizing, or synergistic manner. In clinical studies, preliminary evidence indicates that exercise during neoadjuvant, primary, and adjuvant treatment may enhance efficacy of cancer therapies; however, no clinical study was designed for this purpose. Here we discuss the biological mechanisms of exercise-associated enhancement of therapeutic efficacy and propose future research directions to definitively examine the effects of exercise on cancer treatment and patient outcomes.
我们系统地回顾和综合了关于体育活动/锻炼对癌症治疗效果影响的证据。我们纳入了六项临床前研究和七项临床研究。在八项啮齿动物模型中，运动以附加、致敏或协同的方式显著增强了八种化疗药物和他莫昔芬的疗效。在临床研究中，初步证据表明，在新辅助治疗、主要治疗和辅助治疗期间进行运动可能会增强癌症治疗的疗效；但是，没有一项临床研究是为此目的而设计的。在这里，我们讨论了运动增强治疗效果的生物学机制，并提出了未来的研究方向，以明确检查运动对癌症治疗和患者预后的影响。
