Division of Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Curr Rheumatol Rep. 2021 Jul 3;23(8):59. doi: 10.1007/s11926-021-01027-5.
To highlight the recent discoveries and lines of evidence on the role of microRNAs in ankylosing spondylitis (AS) and psoriatic arthritis (PsA), focusing on their expression profiling and mechanisms of action.
AS and PsA are chronic inflammatory musculoskeletal diseases with axial manifestations and represent an excellent model for studying microRNAs contribution to the disease pathogenesis, particularly through immunomodulation, inflammation, and bone remodelling, or their value as candidate diagnostic and prognostic biomarkers. MicroRNAs are single-stranded nucleotides able to regulate gene expression. They are a key component of the epigenetic machinery, involved in physiological and pathological processes. The contribution of microRNAs in AS and PsA (such as miR-29a in regulating bone metabolism) is highlighted by several works in the field but their utility as possible markers must be still confirmed, particularly in larger patients' cohorts.
强调 microRNAs 在强直性脊柱炎（AS）和银屑病关节炎（PsA）中的作用的最新发现和证据线索，重点关注其表达谱和作用机制。
AS 和 PsA 是慢性炎症性肌肉骨骼疾病，有轴性表现，是研究 microRNAs 对疾病发病机制贡献的极佳模型，特别是通过免疫调节、炎症和骨重塑，或它们作为候选诊断和预后生物标志物的价值。microRNAs 是能够调节基因表达的单链核苷酸。它们是表观遗传机制的关键组成部分，参与生理和病理过程。该领域的几项研究强调了 microRNAs 在 AS 和 PsA 中的作用（如 miR-29a 调节骨代谢），但其作为可能的标志物的效用仍需进一步证实，特别是在更大的患者队列中。
