Department of Radiology Military Institute of Medicine, Warsaw, Poland.
Department of Ophthalmology Military Institute of Medicine, Warsaw, Poland.
Med Ultrason. 2021 Nov 25;23(4):410-417. doi: 10.11152/mu-2954. Epub 2021 Jun 14.
To compare retrobulbar hemodynamic measured by colour Doppler imaging (CDI) in patients with a different severity of glaucoma and to correlate variables CDI with the structural parameters of the retina and optic disc.
Of 89 eyes studied, 31 had preperimetric, 29 early, 12 moderate and 17 advanced glaucoma. Peak systolic velocity (PSV), end-diastolic velocity (EDV), resistance index (RI) in ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary arteries (SPCAs) were evaluated by CDI and compared between study groups. Retinal nerve fibre layer thickness (RNFL) and optic disc parameters measured with optical coherent tomography (OCT) were correlated with the Doppler variables.
In eyes with advanced, moderate and early glaucoma EDV SPCAs were significantly lower as well as RI SPCAs were significantly higher compared to the eyes with preperimetric glaucoma. In eyes with advanced and moderate glaucoma RI CRA (0.74 and 0.71) were significantly higher than in eyes with preperimetric glaucoma (0.68) (p=0.014 and 0.026). In eyes with advanced glaucoma PSV OA and PSV CRA were significantly lower than in eyes with preperimetric glaucoma (32.5 vs. 40.7 cm/s p=0.034 and 8.25 vs. 9.7 cm/s p=0.022, respectively). Positive, variable correlations were found between RNFL and EDV of all measured arteries (0.21<R<0.50, p<0,05).
Statistically significant alterations in the Doppler parameters of retrobulbar arteries in association with thinning of the RNFL were observed in patients with glaucoma along with a greater severity of optic neuropathy.
比较不同严重程度青光眼患者的彩色多普勒成像（CDI）测量的球后血流动力学，并将 CDI 变量与视网膜和视盘的结构参数相关联。
在 89 只眼中，31 只为前期青光眼，29 只为早期青光眼，12 只为中度青光眼，17 只为晚期青光眼。通过 CDI 评估眼动脉（OA）、视网膜中央动脉（CRA）和睫状后短动脉（SPCA）的收缩期峰值速度（PSV）、舒张末期速度（EDV）、阻力指数（RI），并在研究组之间进行比较。用光学相干断层扫描（OCT）测量视网膜神经纤维层厚度（RNFL）和视盘参数，并与多普勒变量相关联。
晚期、中度和早期青光眼患者的 SPCA 舒张末期速度明显较低，SPCA 的 RI 明显较高，与前期青光眼患者相比。晚期和中度青光眼患者的 CRA 的 RI（0.74 和 0.71）明显高于前期青光眼患者（0.68）（p=0.014 和 0.026）。晚期青光眼患者的 OA 和 CRA 的 PSV 明显低于前期青光眼患者（32.5 与 40.7 cm/s，p=0.034 和 8.25 与 9.7 cm/s，p=0.022）。RNFL 与所有测量动脉的 EDV 之间存在正相关（0.21<R<0.50，p<0.05）。
青光眼患者球后动脉多普勒参数与 RNFL 变薄相关，视神经病变严重程度增加。
