Zizas Arminas, Wood Keren, Judickaitė Austėja, Petkus Vytautas, Ragauskas Arminas, Bakstytė Viktorija, Harris Alon, Janulevičienė Ingrida
Department of Ophthalmology, Lithuanian University of Health Sciences, LT-44307 Kaunas, Lithuania.
Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Medicina (Kaunas). 2025 Apr 25;61(5):800. doi: 10.3390/medicina61050800.
: Despite the growing amount of new research, the pathophysiology of glaucoma remains unclear. The aim of this study was to determine the relationship between intracranial pressure (ICP), ocular blood flow and structural optic nerve parameters. A prospective clinical study was conducted involving 24 patients with open-angle glaucoma and 25 healthy controls. Routine clinical examination was performed. Swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA) images were taken (DRI-OCT Triton, Topcon). The vessel density (VD) values of the ONH were calculated around the optic nerve head (ONH). An orbital Doppler device (Vittamed 205, Kaunas, Lithuania) was used for non-invasive ICP measurements. Color Doppler imaging (CDI) (Mindray M7, Shenzhen, China) was used for retrobulbar blood flow measurements in the ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary arteries (SPCAs). : ICP was 8.35 ± 2.8 mmHg in the glaucoma group and 8.45 ± 3.19 mmHg in the control group ( = 0.907). In the glaucoma group, the VD of the superficial vascular plexus in the inferior-nasal (NI) sector of the ONH showed a correlation with ICP (r = 0.451, = 0.05). In contrast, the control group exhibited weaker correlations. CRA peak systolic velocity (PSV) demonstrated significant moderate correlations with VD in multiple retinal layers, including the avascular retina layer in the temporal (T) sector (r = 0.637, = 0.001). : Lower ICP was significantly associated with the lower VD of the superficial plexus layer in the inferior-nasal sector in the glaucoma group, with the control group exhibiting weaker correlations in all sectors. Further longitudinal studies with larger sample sizes are needed to establish associations between intracranial pressure, ocular blood flow and ONH parameters.
尽管新的研究数量不断增加，但青光眼的病理生理学仍不清楚。本研究的目的是确定颅内压（ICP）、眼血流量与视神经结构参数之间的关系。进行了一项前瞻性临床研究，纳入24例开角型青光眼患者和25例健康对照者。进行了常规临床检查。采用扫频光学相干断层扫描（SS-OCT）和OCT血管造影（OCTA）成像（DRI-OCT Triton，拓普康）。计算视神经乳头（ONH）周围的视盘血管密度（VD）值。使用眼眶多普勒设备（Vittamed 205，立陶宛考纳斯）进行无创ICP测量。彩色多普勒成像（CDI）（迈瑞M7，中国深圳）用于测量眼动脉（OA）、视网膜中央动脉（CRA）和睫状后短动脉（SPCA）的球后血流量。青光眼组的ICP为8.35±2.8 mmHg，对照组为8.45±3.19 mmHg（P = 0.907）。在青光眼组中，ONH鼻下（NI）象限浅表血管丛的VD与ICP呈正相关（r = 0.451，P = 0.05）。相比之下，对照组的相关性较弱。CRA的收缩期峰值速度（PSV）与多个视网膜层的VD呈显著中度相关，包括颞侧（T）象限的无血管视网膜层（r = 0.637，P = 0.001）。青光眼组中，较低的ICP与鼻下象限浅表丛层的较低VD显著相关，对照组在所有象限的相关性均较弱。需要进一步进行更大样本量的纵向研究，以确定颅内压、眼血流量和ONH参数之间的关联。
