Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China; Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing, 100037, China; Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China.
Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China; Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing, 100037, China.
Environ Res. 2021 Oct;201:111611. doi: 10.1016/j.envres.2021.111611. Epub 2021 Jul 2.
Although emerging researches have linked ambient fine particulate matter (PM) to obesity, evidence from high-polluted regions is still lacking. We thus assessed the long-term impacts of PM on body mass index (BMI) and the risk of the prevalence of overweight/obesity (BMI≥25 kg/m), by incorporating the well-established Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) project comprising 77,609 participants with satellite-based PM estimates at 1-km spatial resolution. The average of long-term PM level was 70.4 μg/m, with the range of 32.1-94.2 μg/m. Each 10 μg/m increment of PM was associated with 0.421 kg/m (95% confidence interval [CI]: 0.402, 0.439) and 13.5% (95% CI: 12.8%, 14.3%) increased BMI and overweight/obesity risk, respectively. Moreover, compared with the lowest quartile of PM (≤57.5 μg/m), the relative risk of the prevalence of overweight/obesity from the highest quartile (>85.9 μg/m) was 1.611 (95% CI: 1.566, 1.657). The exposure-response curve suggested a non-linear relationship between PM exposure and overweight/obesity. Besides, the association was modified by age, diabetes mellitus, hypertension and dyslipidemia status. Our study provides the evidence for the adverse impacts of long-term PM on BMI and overweight/obesity in China, and the findings are important for policy development on air quality, especially in severely polluted areas.
尽管新兴研究将环境细颗粒物（PM）与肥胖联系起来，但来自高污染地区的证据仍然缺乏。因此，我们通过纳入经过充分验证的中国动脉粥样硬化性心血管疾病风险预测（China-PAR）项目，该项目包含了 77609 名参与者，以及基于卫星的 1 公里空间分辨率的 PM 估计值，评估了 PM 对体重指数（BMI）的长期影响，以及超重/肥胖（BMI≥25 kg/m）的患病率风险。长期 PM 水平的平均值为 70.4μg/m，范围为 32.1-94.2μg/m。PM 每增加 10μg/m，BMI 就会增加 0.421kg/m（95%置信区间[CI]：0.402，0.439）和超重/肥胖风险增加 13.5%（95% CI：12.8%，14.3%）。此外，与 PM（≤57.5μg/m）的最低四分位数相比，PM（>85.9μg/m）的最高四分位数与超重/肥胖患病率的相对风险为 1.611（95% CI：1.566，1.657）。暴露-反应曲线表明 PM 暴露与超重/肥胖之间存在非线性关系。此外，这种关联还受到年龄、糖尿病、高血压和血脂异常状态的影响。我们的研究为长期 PM 对中国 BMI 和超重/肥胖的不良影响提供了证据，这一发现对于空气质量政策的制定非常重要，特别是在污染严重的地区。
