Department of Computer Science and Engineering, Visvesvaraya National Institute of Technology, Nagpur, 440010, India.
Indian Institute of Information Technology, Nagpur, 440006, India.
Comput Biol Med. 2021 Aug;135:104564. doi: 10.1016/j.compbiomed.2021.104564. Epub 2021 Jun 18.
Although biopsy is the gold standard for tumour grading, being invasive, this procedure also proves fatal to the brain. Thus, non-invasive methods for brain tumour grading are urgently needed. Here, a magnetic resonance imaging (MRI)-based non-invasive brain tumour grading method has been proposed using deep learning (DL) and machine learning (ML) techniques.
Four clinically applicable datasets were designed. The four datasets were trained and tested on five DL-based models (convolutional neural networks), AlexNet, VGG16, ResNet18, GoogleNet, and ResNet50, and five ML-based models, Support Vector Machine, K-Nearest Neighbours, Naïve Bayes, Decision Tree, and Linear Discrimination using five-fold cross-validation. A majority voting (MajVot)-based ensemble algorithm has been proposed to optimise the overall classification performance of five DL and five ML-based models.
The average accuracy improvement of four datasets using the DL-based MajVot algorithm against AlexNet, VGG16, ResNet18, GoogleNet, and ResNet50 models was 2.02%, 1.11%, 1.04%, 2.67%, and 1.65%, respectively. Further, a 10.12% improvement was seen in the average accuracy of four datasets using the DL method against ML. Furthermore, the proposed DL-based MajVot algorithm was validated on synthetic face data and improved the male versus female face image classification accuracy by 2.88%, 0.71%, 1.90%, 2.24%, and 0.35% against AlexNet, VGG16, ResNet18, GoogleNet, and ResNet50, respectively.
The proposed MajVot algorithm achieved promising results for brain tumour classification and is able to utilise the combined potential of multiple models.
虽然活检是肿瘤分级的金标准,但具有侵袭性,这一过程对大脑也有致命风险。因此,急需非侵入性的脑肿瘤分级方法。在这里,提出了一种基于磁共振成像(MRI)的非侵入性脑肿瘤分级方法,该方法使用深度学习(DL)和机器学习(ML)技术。
设计了四个临床适用的数据集。四个数据集在五个基于 DL 的模型(卷积神经网络)上进行训练和测试,分别是 AlexNet、VGG16、ResNet18、GoogleNet 和 ResNet50,以及五个基于 ML 的模型,支持向量机、K-最近邻、朴素贝叶斯、决策树和线性判别使用五折交叉验证。提出了一种基于多数投票(MajVot)的集成算法,以优化五个基于 DL 和五个基于 ML 的模型的整体分类性能。
使用基于 DL 的 MajVot 算法对四个数据集的平均准确率提高了 2.02%、1.11%、1.04%、2.67%和 1.65%,分别为 AlexNet、VGG16、ResNet18、GoogleNet 和 ResNet50 模型。此外,使用 ML 方法对四个数据集的平均准确率提高了 10.12%。此外,还在合成人脸数据上验证了所提出的基于 DL 的 MajVot 算法,该算法将男性与女性人脸图像分类准确率提高了 2.88%、0.71%、1.90%、2.24%和 0.35%,分别为 AlexNet、VGG16、ResNet18、GoogleNet 和 ResNet50。
所提出的 MajVot 算法在脑肿瘤分类方面取得了有前景的结果,并且能够利用多个模型的综合潜力。