被忽视的重度/极重度智力残疾人群痴呆问题：观察症状的系统文献回顾
The neglected puzzle of dementia in people with severe/profound intellectual disabilities: A systematic literature review of observable symptoms.
机构信息
Department of Neurology and Alzheimer Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Research Group Healthy Ageing, Allied Health Care and Nursing, Hanze University of Applied Sciences, Groningen, The Netherlands.
出版信息
J Appl Res Intellect Disabil. 2022 Jan;35(1):24-45. doi: 10.1111/jar.12920. Epub 2021 Jul 4.
BACKGROUND
Dementia is increasingly prevalent in people with severe/profound intellectual disabilities. However, early detection and diagnosis of dementia is complex in this population. This study aimed to identify observable dementia symptoms in adults with severe/profound intellectual disabilities in available literature.
METHOD
A systematic literature search was conducted in PubMed, PsycINFO and Web of Science with an exhaustive search string using a combination of search terms for severe/profound intellectual disabilities and dementia/ageing.
RESULTS
Eleven studies met inclusion criteria. Cognitive decline, behavioural and psychological alterations, decline in activities of daily living as well as neurological and physical changes were found.
CONCLUSIONS
Only a very limited number of studies reported symptoms ascribed to dementia in adults with severe/profound intellectual disabilities. Given the complexity of signalling and diagnosing dementia, dedicated studies are required to unravel the natural history of dementia in this population.
背景
痴呆在严重/极重度智力障碍人群中越来越普遍。然而，在该人群中，痴呆的早期检测和诊断较为复杂。本研究旨在从现有文献中确定严重/极重度智力障碍成年人中可观察到的痴呆症状。
方法
通过使用严重/极重度智力障碍和痴呆/衰老的组合搜索词，在 PubMed、PsycINFO 和 Web of Science 中进行了系统的文献检索，采用穷尽式搜索策略。
结果
符合纳入标准的研究有 11 项。研究发现认知能力下降、行为和心理改变、日常生活活动能力下降以及神经和身体变化。
结论
只有极少数研究报告了严重/极重度智力障碍成年人中与痴呆相关的症状。鉴于痴呆信号和诊断的复杂性，需要专门的研究来揭示该人群中痴呆的自然史。
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