Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia.
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
J Alzheimers Dis. 2021;82(4):1809-1822. doi: 10.3233/JAD-210185.
Greater neuroticism has been associated with higher risk for Alzheimer's disease (AD) dementia. However, the directionality of this association is unclear. We examined whether personality traits differ between cognitively-unimpaired carriers of autosomal-dominant AD (ADAD) and non-carriers, and are associated with in vivo AD pathology.
To determine whether personality traits differ between cognitively unimpaired ADAD mutation carriers and non-carriers, and whether the traits are related to age and AD biomarkers.
A total of 33 cognitively-unimpaired Presenilin-1 E280A mutation carriers and 41 non-carriers (ages 27-46) completed neuropsychological testing and the NEO Five-Factor Personality Inventory. A subsample (n = 46; 20 carriers) also underwent tau and amyloid PET imaging.
Carriers reported higher neuroticism relative to non-carriers, although this difference was not significant after controlling for sex. Neuroticism was positively correlated with entorhinal tau levels only in carriers, but not with amyloid levels.
The finding of higher neuroticism in carriers and the association of this trait with tau pathology in preclinical stages of AD highlights the importance of including personality measures in the evaluation of individuals at increased risk for cognitive impairment and dementia. Further research is needed to characterize the mechanisms of these relationships.
较高的神经质与阿尔茨海默病（AD）痴呆的风险增加有关。然而，这种关联的方向性尚不清楚。我们研究了认知正常的常染色体显性 AD（ADAD）携带者和非携带者之间的人格特质是否存在差异，以及这些特质是否与 AD 病理学有关。
确定认知正常的 ADAD 突变携带者和非携带者之间的人格特质是否存在差异，以及这些特质是否与年龄和 AD 生物标志物有关。
共有 33 名认知正常的早老素-1 E280A 突变携带者和 41 名非携带者（年龄 27-46 岁）完成了神经心理学测试和 NEO 五因素人格量表。一个亚组（n = 46；20 名携带者）还进行了 tau 和淀粉样蛋白 PET 成像。
携带者报告的神经质水平高于非携带者，但在控制性别后，这种差异并不显著。神经质仅在携带者中与内嗅皮层 tau 水平呈正相关，而与淀粉样蛋白水平无关。
携带者中神经质水平较高，以及该特质与 AD 临床前阶段 tau 病理学的关联，强调了在评估认知障碍和痴呆风险增加的个体时纳入人格测量的重要性。需要进一步研究来描述这些关系的机制。
