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评价 Notch-2/Jagged-1 在 2 型糖尿病患者中的遗传关联与表达。

Evaluation of the Genetic Association and Expressions of Notch-2 /Jagged-1 in Patients with Type 2 Diabetes Mellitus.

机构信息

Department of Biology and Biotechnology, American University of Madaba, Madaba, Jordan.

Department of Microbiology, Faculty of Medicine, University of Kufa, Kufa, Iraq.

出版信息

Med Arch. 2021 Apr;75(2):101-108. doi: 10.5455/medarh.2021.75.101-108.

DOI:10.5455/medarh.2021.75.101-108
PMID:34219868
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8228649/
Abstract

BACKGROUND

Diabetes mellitus (DM) is the world's most common cause of chronic kidney diseases (CKD), with approximately 1 in 4 adults with DM having CKD and 1 out of 10 to 20% of DM patients die from CKD.

OBJECTIVE

The current study aims to investigate the correlation between Notch-2 and Jag-1expressions and specific inflammation biomarkers IL-1β and IL-6 with different stages of diabetic nephropathy.

METHODS

From August 2018 to January 2019, three hundred subjects were recruited for this study. One hundred and fifty subjects were healthy and age-matched to the diabetic group and selected as a control group. Another 150 patients with an established diagnosis of type 2 diabetes (T2DM) according to the criteria of the American Diabetes Association (ADA) were also recruited. Blood specimens were eventually used to identify the expressions Notch-2 and Jagged-1 and the levels of inflammatory biomarkers IL-1β and IL-6.

RESULT

The current study shows a significant increase in gene expression and inflammatory biomarkers in patients with moderate and severe diabetic nephropathy compared to the control group. However, there was no significant difference between healthy control and mild diabetic nephropathy patients. This study shows a close association between the increase in the levels of inflammatory biomarkers IL-1β and IL-6 as well as the gene expressions levels of both Notch-2 and Jag-1 with human diabetic nephropathy.

CONCLUSION

According to our findings, we emphasize the use of Notch-2 and Jag-1 expressions and IL-1β and IL-6 levels as potential biomarkers for different stages of diabetic nephropathy.

摘要

背景

糖尿病（DM）是全球最常见的慢性肾脏病（CKD）病因，约每 4 名成年 DM 患者中就有 1 人患有 CKD，10%至 20%的 DM 患者死于 CKD。

目的

本研究旨在探讨 Notch-2 和 Jag-1 表达与不同分期糖尿病肾病特异性炎症标志物白细胞介素-1β（IL-1β）和白细胞介素-6（IL-6）之间的相关性。

方法

本研究于 2018 年 8 月至 2019 年 1 月招募了 300 名受试者。其中 150 名健康受试者与糖尿病组年龄匹配，作为对照组。另外 150 名根据美国糖尿病协会（ADA）标准确诊为 2 型糖尿病（T2DM）的患者也被纳入研究。最终使用血液标本鉴定 Notch-2 和 Jagged-1 的表达及炎症标志物 IL-1β和 IL-6 的水平。

结果

本研究显示，与对照组相比，中重度糖尿病肾病患者的基因表达和炎症标志物水平显著增加。然而，健康对照组与轻度糖尿病肾病患者之间无显著差异。本研究表明，炎症标志物 IL-1β和 IL-6 水平以及 Notch-2 和 Jag-1 的基因表达水平升高与人类糖尿病肾病密切相关。

结论

根据我们的发现，我们强调 Notch-2 和 Jag-1 表达以及 IL-1β 和 IL-6 水平可作为不同分期糖尿病肾病的潜在生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6266/8228649/a1e4c9871f26/medarch-75-101-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6266/8228649/d82cc4faa974/medarch-75-101-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6266/8228649/18733859efb3/medarch-75-101-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6266/8228649/e97ea39925dd/medarch-75-101-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6266/8228649/f5c851c107e3/medarch-75-101-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6266/8228649/643dcc33686b/medarch-75-101-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6266/8228649/a1e4c9871f26/medarch-75-101-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6266/8228649/d82cc4faa974/medarch-75-101-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6266/8228649/18733859efb3/medarch-75-101-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6266/8228649/e97ea39925dd/medarch-75-101-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6266/8228649/f5c851c107e3/medarch-75-101-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6266/8228649/643dcc33686b/medarch-75-101-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6266/8228649/a1e4c9871f26/medarch-75-101-g006.jpg

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