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局部切除显示脉络膜黑素细胞瘤的组织病理学和免疫组化:一例报告

Histopathology and immunohistochemistry of choroidal melanocytoma demonstrated by local resection: A case report.

作者信息

Goto Hiroshi, Yamakawa Naoyuki, Komatsu Hiroyuki

机构信息

Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

出版信息

Am J Ophthalmol Case Rep. 2021 Jun 19;23:101147. doi: 10.1016/j.ajoc.2021.101147. eCollection 2021 Sep.

Abstract

PURPOSE

To describe the clinical and histopathological features of a case of choroidal melanocytoma treated by local resection.

OBSERVATIONS

A 73-year-old man was referred to our hospital with a clinical diagnosis of choroidal melanoma. His best corrected visual acuity at presentation was 20/20 OU. Ocular fundus examination of his right eye showed a pigmented intraocular tumor. Local resection of the tumor was performed under general anesthesia. Histopathological examination of the excised tumor showed proliferation of round to ovoid cells with abundant cytoplasm containing many melanosomes and uniform nuclei and these histopathological findings were compatible with a diagnosis of choroidal melanocytoma. Visual acuity of 20/200 OD has been maintained for over 4 years without local recurrence.

CONCLUSIONS AND IMPORTANCE

Clinical diagnosis of choroidal melanocytoma, especially differentiation from melanoma, is difficult and challenging. Local resection of the tumor allowed study of the histopathological features of the choroidal melanocytoma and maintained tolerable vision in the current case.

摘要

目的

描述1例经局部切除治疗的脉络膜黑素细胞瘤的临床及组织病理学特征。

观察结果

一名73岁男性因临床诊断为脉络膜黑色素瘤转诊至我院。初诊时其最佳矫正视力为双眼20/20。右眼眼底检查发现一个色素性眼内肿瘤。在全身麻醉下对肿瘤进行了局部切除。切除肿瘤的组织病理学检查显示,圆形至椭圆形细胞增生,细胞质丰富,含有许多黑素小体,细胞核均匀,这些组织病理学表现符合脉络膜黑素细胞瘤的诊断。右眼视力20/200已维持4年多,无局部复发。

结论与意义

脉络膜黑素细胞瘤的临床诊断,尤其是与黑色素瘤的鉴别诊断困难且具有挑战性。肿瘤局部切除有助于研究脉络膜黑素细胞瘤的组织病理学特征,并在本例中维持了可耐受的视力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6049/8242962/80b1b01e57e7/gr1.jpg

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