银屑病患者内脏脂肪标志物与心脏代谢疾病风险之间的关系。
The relation between visceral fat markers and cardiometabolic disease risks in psoriasis patients.
作者信息
Ataseven Arzu, Kutlu Ruhusen, Uzun Latife
机构信息
Department of Dermatology, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey.
Department of Family Medicine, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey.
出版信息
North Clin Istanb. 2021 May 24;8(3):203-211. doi: 10.14744/nci.2020.41961. eCollection 2021.
OBJECTIVE
Psoriasis is a chronic, inflammatory disease that appears with variable trigger factors. We know that obesity and other metabolic syndrome criteria are high in psoriasis patients. The aim of this study is to evaluate the relationship between visceral fat markers, risk of cardiometabolic disease, and psoriasis area severity index (PASI) in individuals with and without psoriasis.
METHODS
A total of 203 subjects, 102 psoriasis patients and 101 healthy individuals, were included in the study. Lipid accumulation product (LAP) index, visceral adiposity index (VAI), plasma atherogenicity index (PAI), body mass index (BMI), PASI, triglyceride (TG), and high-density lipoprotein cholesterol (HDL-c) values were measured.
RESULTS
LAP index, VAI, PAI, BMI, and TG levels were significantly high (p<0.001) and HDL-c levels were significantly low (p=0.009) in patients with psoriasis compared to healthy individuals.
CONCLUSION
LAP index, VAI, and PAI calculations can be recommended as a potential biomarker for early diagnosis of cardiometabolic diseases common in patients with psoriasis.
目的
银屑病是一种慢性炎症性疾病，其发病有多种触发因素。我们知道银屑病患者中肥胖及其他代谢综合征标准的发生率较高。本研究的目的是评估有银屑病和无银屑病个体的内脏脂肪标志物、心血管代谢疾病风险与银屑病面积和严重程度指数（PASI）之间的关系。
方法
本研究共纳入203名受试者，其中102名银屑病患者和101名健康个体。测量了脂质蓄积产物（LAP）指数、内脏脂肪指数（VAI）、血浆致动脉粥样硬化指数（PAI）、体重指数（BMI）、PASI、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-c）值。
结果
与健康个体相比，银屑病患者的LAP指数、VAI、PAI、BMI和TG水平显著升高（p<0.001），HDL-c水平显著降低（p=0.009）。
结论
LAP指数、VAI和PAI计算可作为银屑病患者常见心血管代谢疾病早期诊断的潜在生物标志物。
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