Paediatrics, Nutrition, and Development Research Unit, Universitat Rovira I Virgili - IISPV, C/ Sant Llorenç 21, 43201, Reus, Spain; Serra Hunter Fellow, Spain.
Paediatrics, Nutrition, and Development Research Unit, Universitat Rovira I Virgili - IISPV, C/ Sant Llorenç 21, 43201, Reus, Spain.
Clin Nutr. 2021 Jul;40(7):4606-4614. doi: 10.1016/j.clnu.2021.06.001. Epub 2021 Jun 8.
BACKGROUND & AIMS: it has previously been described that dietary patterns established early in life tracked to late childhood. The aim of the present work was to analyse the association of dietary patterns that tracked from 2 to 8y with cardiometabolic markers at 8y of age.
The 3 identified patterns at 2y (that previous analyses showed to track to age 8y) were: "Core", loaded for vegetables, fruits, fish, olive oil, etc.; "F&S", loaded by poor-quality fats and sugars; and "Protein", mainly loaded by animal protein sources. Cardiometabolic markers at 8y were systolic blood pressure (SBP), insulin resistance (HOMA-IR), and triglycerides, and BMI z-score. To examine whether the association of diet with the outcomes was the result of a direct effect of diet at either two or 8y, or synergy between them, we used structural equation models.
the associations between the patterns and the health outcomes were: Core was inversely associated with SBP and HOMA-IR; Protein was directly associated with HOMA-IR and SBP; and adherence to F&S was directly associated with triglycerides and SBP. The associations between the patterns and the health outcomes were independent of BMI and were the result of a direct effect of diet at 2y, an indirect effect of diet at 2y through diet at 8y or a combination between both pathways.
dietary patterns acquired in early life, persisting to later childhood, were associated with cardiometabolic markers at school age independently of BMI.
先前已有研究表明，生命早期形成的饮食模式会持续到儿童晚期。本研究旨在分析从 2 岁到 8 岁追踪到的饮食模式与 8 岁时心血管代谢标志物之间的相关性。
在 2 岁时识别出的 3 种模式（之前的分析表明这些模式会持续到 8 岁）为：“核心”模式，富含蔬菜、水果、鱼类、橄榄油等；“F&S”模式，富含低质量脂肪和糖；以及“蛋白质”模式，主要由动物蛋白来源构成。8 岁时的心血管代谢标志物包括收缩压（SBP）、胰岛素抵抗（HOMA-IR）和甘油三酯，以及 BMI 得分。为了研究饮食与结果之间的相关性是否是饮食在 2 岁或 8 岁时的直接作用，或者是它们之间的协同作用，我们使用结构方程模型进行了分析。
模式与健康结果之间的相关性为：“核心”模式与 SBP 和 HOMA-IR 呈负相关；“蛋白质”模式与 HOMA-IR 和 SBP 呈正相关；而“F&S”模式与甘油三酯和 SBP 呈正相关。模式与健康结果之间的相关性独立于 BMI，并且是 2 岁时饮食的直接作用、通过 8 岁时饮食的间接作用或这两种途径的组合的结果。
生命早期获得的、持续到儿童晚期的饮食模式与学龄期的心血管代谢标志物有关，与 BMI 无关。
