Metabolomics Research Group, Instituto de Química, Universidade Federal da Bahia, Rua Barão de Jeremoabo s/n, 40170-115 Salvador, Brazil.
Laboratório de Neuroquímica e Biologia Celular, Departamento de Bioquímica e Biofísica, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Food Chem. 2021 Dec 15;365:130479. doi: 10.1016/j.foodchem.2021.130479. Epub 2021 Jun 27.
Corn silk has been widely used as a nutritional and medicinal supplement due to its pharmacological properties, but there is a lack of studies that correlate the extracts' chemical composition with their biological activities. Herein, we performed the large-scale chemical characterization of corn silk extracts and used chemometrics to correlate the chemical composition with the biological activities of the extracts. Twenty-two metabolites were identified by High-Performance Liquid Chromatography coupled to Mass Spectrometry (HPLC-MS), whereas twelve were identified by Gas Chromatography coupled to Mass Spectrometry (GC-MS). Chemometrics allowed us to discriminate extracts obtained in different organic solvents from in natura and commercial product samples and to pinpoint potential candidate metabolites for the antioxidant and anti-glioma activities. Two flavone glycosides (7 and 8), along with a O-methylated anthocyanidin (26) seems to be the main contributors for the biological activities of the corn silk extracts.
玉米须因其药理学特性而被广泛用作营养和药用补充剂，但缺乏将提取物的化学成分与其生物活性相关联的研究。在此，我们对玉米须提取物进行了大规模的化学表征，并使用化学计量学将化学成分与提取物的生物活性相关联。通过高效液相色谱-质谱联用 (HPLC-MS) 鉴定了 22 种代谢物，而通过气相色谱-质谱联用 (GC-MS) 鉴定了 12 种代谢物。化学计量学允许我们区分在不同有机溶剂中获得的提取物与在天然和商业产品样品中的提取物，并确定潜在的候选代谢物，用于抗氧化和抗神经胶质瘤活性。两种黄酮糖苷（7 和 8）以及一种 O-甲基化的花青素（26）似乎是玉米须提取物生物活性的主要贡献者。
