American Medical Group Association, Alexandria, VA
National Kidney Foundation, New York, NY.
Diabetes Care. 2021 Sep;44(9):2000-2009. doi: 10.2337/dc20-2715. Epub 2021 Jul 7.
Clinical guidelines for people with diabetes recommend chronic kidney disease (CKD) testing at least annually using estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (uACR). We aimed to understand CKD testing among people with type 2 diabetes in the U.S.
Electronic health record data were analyzed from 513,165 adults with type 2 diabetes receiving primary care from 24 health care organizations and 1,164 clinical practice sites. We assessed the percentage of patients with both one or more eGFRs and one or more uACRs and each test individually in the 1, 2, and 3 years ending September 2019 by health care organization and clinical practice site. Elevated albuminuria was defined as uACR ≥30 mg/g.
The 1-year median testing rate across organizations was 51.6% for both uACR and eGFR, 89.5% for eGFR, and 52.9% for uACR. uACR testing varied (10th-90th percentile) from 44.7 to 63.3% across organizations and from 13.3 to 75.4% across sites. Over 3 years, the median testing rate for uACR across organizations was 73.7%. Overall, the prevalence of detected elevated albuminuria was 15%. The average prevalence of detected elevated albuminuria increased linearly with uACR testing rates at sites, with estimated prevalence of 6%, 15%, and 30% at uACR testing rates of 20%, 50%, and 100%, respectively.
While eGFR testing rates are uniformly high among people with type 2 diabetes, testing rates for uACR are suboptimal and highly variable across and within the organizations examined. Guideline-recommended uACR testing should increase detection of CKD.
针对糖尿病患者的临床指南建议,至少每年使用估算肾小球滤过率(eGFR)和尿白蛋白与肌酐比值(uACR)进行慢性肾脏病(CKD)检测。我们旨在了解美国 2 型糖尿病患者的 CKD 检测情况。
从 24 个医疗保健组织和 1164 个临床实践站点的 513,165 名接受初级保健的 2 型糖尿病成人的电子健康记录数据中进行了分析。我们评估了在 2019 年 9 月结束的 1、2 和 3 年内,每个医疗保健组织和临床实践站点接受过一次或多次 eGFR 和一次或多次 uACR 检测的患者比例,以及每个测试的比例。白蛋白尿升高定义为 uACR≥30mg/g。
在组织中,1 年内 uACR 和 eGFR 的中位检测率为 51.6%,eGFR 为 89.5%,uACR 为 52.9%。uACR 检测率(第 10 至 90 百分位数)在组织之间从 44.7%到 63.3%不等,在站点之间从 13.3%到 75.4%不等。在 3 年内,uACR 在组织中的中位检测率为 73.7%。总体而言,检测到的白蛋白尿升高的患病率为 15%。在站点中,uACR 检测率与检测到的白蛋白尿升高的患病率呈线性增加,uACR 检测率分别为 20%、50%和 100%时,估计的患病率分别为 6%、15%和 30%。
尽管 2 型糖尿病患者的 eGFR 检测率普遍较高,但 uACR 的检测率不理想,且在检查的组织之间和内部差异很大。建议的 uACR 检测应该会增加 CKD 的检出率。