Barnard Anne M L, Fairhead Heather I M
Phico Therapeutics Ltd, Bertarelli Building, Bourn Hall, High Street, Bourn CB23 2TN, UK.
Phico Therapeutics Ltd, Bertarelli Building, Bourn Hall, High Street, Bourn CB23 2TN, UK.
Drug Discov Today. 2021 Sep;26(9):2095-2098. doi: 10.1016/j.drudis.2021.06.013. Epub 2021 Jul 6.
The use of engineered phages offers a unique opportunity to improve on wild-type (WT) phages to generate ever more successful therapeutics to combat bacterial infections. Here, we discuss how phage engineering could be used to overcome some of the technical challenges of phage therapy, and suggest some areas in which more research will be crucial to the development of further novel phage therapeutics.
使用经过工程改造的噬菌体提供了一个独特的机会，可以对野生型（WT）噬菌体进行改进，以产生更成功的治疗方法来对抗细菌感染。在这里，我们讨论了噬菌体工程如何用于克服噬菌体治疗的一些技术挑战，并指出了一些领域，在这些领域中，更多的研究对于进一步开发新型噬菌体治疗方法至关重要。
